Title:
METHOD OF SEARCHING FOR REMEDY FOR HEPATITIS D
Document Type and Number:
WIPO Patent Application WO/2002/068655
Kind Code:
A1
Abstract:
A test compound is added to a system containing the full amino acid sequence of hepatitis D virus antigen (hereinafter referred to as HDV antigen) or a part of the same, a polypeptide binding to RNA polymerase II (hereinafter referred to as HDV antigen polypeptide) and RNA polymerase II. Then the binding level of the HDV antigen polypeptide to RNA polymerase II is measured and compared with the corresponding binding level in the absence of the test compound. Thus, a compound inhibiting the binding is screened. Also, a test compound is added to a system containing the HDV antigen polypeptide and thus a compound capable of binding to the HDV antigen polypeptide is screened.
Inventors:
HANDA HIROSHI (JP)
YAMAGUCHI YUKI (JP)
YAMAGUCHI YUKI (JP)
Application Number:
PCT/JP2002/001817
Publication Date:
September 06, 2002
Filing Date:
February 27, 2002
Export Citation:
Assignee:
CIRCLE PROMOTION SCIENCE & ENG (JP)
KYOWA HAKKO KOGYO KK (JP)
HANDA HIROSHI (JP)
YAMAGUCHI YUKI (JP)
KYOWA HAKKO KOGYO KK (JP)
HANDA HIROSHI (JP)
YAMAGUCHI YUKI (JP)
International Classes:
A61P31/20; C07K14/08; C12N1/19; C12N1/21; C12N15/51; G01N33/576; A61K38/00; (IPC1-7): C12N15/51; A61K45/00; A61P31/20; C07K14/08; C07K16/10; C07K19/00; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/48; C12Q1/68; G01N33/15; G01N33/50
Foreign References:
| EP0251575A1 | 1988-01-07 | |||
| US3557292A | 1971-01-19 | |||
| JPS58174371A | 1983-10-13 | |||
| JPS4972277A | 1974-07-12 | |||
| US3689646A | 1972-09-05 | |||
| JPS4816608B1 | 1973-05-23 | |||
| US4517172A | 1985-05-14 |
Other References:
YAMAGUCHI Y. ET AL.: "Stimulation of RNA polymerase II elongation by hepatitis delta antigen", SCIENCE, vol. 293, no. 5527, 6 July 2001 (2001-07-06), pages 124 - 127, XP002952431
YAMAGUCHI YAKI ET AL.: "D-gata kan'en virus (HDV) no zoshoku mechanism", GENE & MEDICINE, vol. 5, no. 4, 10 November 2001 (2001-11-10), pages 664 - 669, XP002952474
LEE C.H. ET AL.: "The nucleolin binding activity of hepatitis delta antigen is associated with nucleolus targeting", J. BIOL. CHEM., vol. 273, no. 13, 1998, pages 7650 - 7656, XP002952432
DE BRUIN W. ET AL.: "In vitro binding properties of the hepatitis delta antigens to the hepatitis B virus envelop proteins: potential significance for the formation of delta particles", VIRUS RES., vol. 31, no. 1, 1994, pages 27 - 37, XP002952433
POISSON F. ET AL.: "Characterization of RNA-binding domains of hepatitis delta antigen", J. GEN. VIROL., vol. 74, no. PT. 11, 1993, pages 2473 - 2478, XP002952434
IMAZEKI F. ET AL.: "Heterogeneity and evolution rates of delta virus RNA sequences", J. VIROL., vol. 64, no. 11, 1990, pages 5594 - 5599, XP001073432
CASEY J.L. ET AL.: "A genotype of hepatitis D virus that occurs in northern South America", PROC. NATL. ACAD. SCI. USA, vol. 90, no. 19, 1993, pages 9016 - 9020, XP002952435
LO K. ET AL.: "Inhibition of cellular RNA polymerase II transcription by delta antigen of hepatitis delta virus", VIROLOGY, vol. 247, no. 2, 1998, pages 178 - 188, XP002952436
YAMAGUCHI YAKI ET AL.: "D-gata kan'en virus (HDV) no zoshoku mechanism", GENE & MEDICINE, vol. 5, no. 4, 10 November 2001 (2001-11-10), pages 664 - 669, XP002952474
LEE C.H. ET AL.: "The nucleolin binding activity of hepatitis delta antigen is associated with nucleolus targeting", J. BIOL. CHEM., vol. 273, no. 13, 1998, pages 7650 - 7656, XP002952432
DE BRUIN W. ET AL.: "In vitro binding properties of the hepatitis delta antigens to the hepatitis B virus envelop proteins: potential significance for the formation of delta particles", VIRUS RES., vol. 31, no. 1, 1994, pages 27 - 37, XP002952433
POISSON F. ET AL.: "Characterization of RNA-binding domains of hepatitis delta antigen", J. GEN. VIROL., vol. 74, no. PT. 11, 1993, pages 2473 - 2478, XP002952434
IMAZEKI F. ET AL.: "Heterogeneity and evolution rates of delta virus RNA sequences", J. VIROL., vol. 64, no. 11, 1990, pages 5594 - 5599, XP001073432
CASEY J.L. ET AL.: "A genotype of hepatitis D virus that occurs in northern South America", PROC. NATL. ACAD. SCI. USA, vol. 90, no. 19, 1993, pages 9016 - 9020, XP002952435
LO K. ET AL.: "Inhibition of cellular RNA polymerase II transcription by delta antigen of hepatitis delta virus", VIROLOGY, vol. 247, no. 2, 1998, pages 178 - 188, XP002952436
Attorney, Agent or Firm:
Ishida, Takashi (ISHIDA & ASSOCIATES Toranomon 37 Mori
Bldg., 5-1, Toranomon 3-chom, Minato-ku Tokyo, JP)
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