Title:
METHOD FOR SEPARATING COENZYME Q10 BY MEANS OF USING SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2021/232543
Kind Code:
A1
Abstract:
Disclosed is a method for separating coenzyme Q10 by means of using a supercritical fluid chromatography system, the method comprising: (1) starting a supercritical fluid chromatography system and setting system parameters; (2) once the system is operating stably, a chromatographic column is sufficiently balanced and a baseline is stable, injecting a coenzyme Q10 feeding solution and collecting a coenzyme Q10 component according to an ultraviolet peak signal at an output peak; and (3) removing a solvent from the coenzyme Q10 component to obtain high-purity coenzyme Q10. By means of the method, a supercritical fluid chromatography system-based separation method is used to treat a crude coenzyme Q10 extract for the first time and the coenzyme Q10 can be successfully separated from homologs thereof; the obtained coenzyme Q10 has relatively high purity and yield; and the method has low organic waste liquid emissions and a low amount of pollution, consumes a short amount of time, and has high separation efficiency, and has the characteristics of being economical and highly efficient, having easy operations, and being environmentally friendly.
Inventors:
HU ZEJUN (CN)
WANG BINGRONG (CN)
LIAO WEICHENG (CN)
DOU CHANYU (CN)
HE QINGFEI (CN)
WANG BINGRONG (CN)
LIAO WEICHENG (CN)
DOU CHANYU (CN)
HE QINGFEI (CN)
Application Number:
PCT/CN2020/098746
Publication Date:
November 25, 2021
Filing Date:
June 29, 2020
Export Citation:
Assignee:
INNER MONGOLIA KINGDOMWAY PHARMACEUTICAL LTD (CN)
XIAMEN KINGDOMWAY GROUP COMPANY (CN)
XIAMEN KINGDOMWAY GROUP COMPANY (CN)
International Classes:
C07C46/10; C07C50/06; G01N30/02
Foreign References:
| CN110944970A | 2020-03-31 | |||
| US20110137084A1 | 2011-06-09 | |||
| CN101111465A | 2008-01-23 | |||
| US6984308B2 | 2006-01-10 | |||
| CN110465114A | 2019-11-19 | |||
| US20040033553A1 | 2004-02-19 | |||
| CN110231425A | 2019-09-13 | |||
| CN103196860A | 2013-07-10 |
Other References:
ATSUKI MATSUBARA ET AL.: "High-accuracy analysis system for the redox status of coenzyme Q10 by online supercritical fluid extraction-supercritical fluid chromatography/mass spectrometry", JOURNAL OF CHROMATOGRAPHY A, vol. 1250, 31 December 2012 (2012-12-31), pages 76 - 79, XP028426688, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2012.05.009
Attorney, Agent or Firm:
XIAMEN JINGCHENGXINCHUANG INTELLECTUAL PROPERTY AGENCY CO. LTD (CN)
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