METHOD FOR SEPARATING AND PURIFYING ASPARTAME AND ASPARTAME DERIVATIVE

Title:

METHOD FOR SEPARATING AND PURIFYING ASPARTAME AND ASPARTAME DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1999/029713

Kind Code:

A1

Abstract:

A method for efficiently separating aspartame (APM) from APM derivative N-[N-(3,3-dimethylbutyl)-L-$g(a)-aspartyl]-L-phenylalanine methyl ester and thus purifying APM and the above-mentioned APM derivative each at a high purity, which comprises subjecting, for example, an aqueous solution containing APM and APM derivative to column chromatography with the use of a nonpolar highly porous polymer resin.

Inventors:

NAGASHIMA KAZUTAKA (JP)
KISHISHITA AKIHIRO (JP)

Application Number:

PCT/JP1998/005533

Publication Date:

June 17, 1999

Filing Date:

December 07, 1998

Export Citation:

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Assignee:

AJINOMOTO KK (JP)
NAGASHIMA KAZUTAKA (JP)
KISHISHITA AKIHIRO (JP)

International Classes:

C07K1/16; A23L27/30; C07K5/072; C07K5/075; (IPC1-7): C07K5/075; A23L1/236; C07K1/16

Domestic Patent References:

WO1998032767A1	1998-07-30
WO1995030689A1	1995-11-16
WO1998039979A1	1998-09-17

Foreign References:

JPH08503206A	1996-04-09
JPS497245A	1974-01-22

Other References:

MATTERN R.H. et al., "Conformational Analysis of Potent Sweet Taste Ligands by Nuclear Magnetic Resonance, Computer Stimulations and X-Ray Diffraction Studies", J. PEPTIDE RES., (Oct. 1997), Vol. 50, No. 4, p. 286-299.
GOODMAN M. et al., "X-Ray Structures of New Dipeptide Taste Ligands", J. PEPTIDE SCI., (Jun. 1998), Vol. 4, No. 4, p. 229-238.

Attorney, Agent or Firm:

Ishida, Yasumasa (7th floor 20-12 Shin-Yokohama 3-chome Kohoku-ku, Yokohama-shi Kanagawa-ken, JP)

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