Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR STABILIZING DIBUTYLHYDROXYTOLUENE
Document Type and Number:
WIPO Patent Application WO/2015/137326
Kind Code:
A1
Abstract:
The objective of the present invention is to provide a technique for increasing the thermal stability of dibutylhydroxytoluene and suppressing a decrease in the content thereof over time in a liquid drug that includes dibutylhydroxytoluene and pranoprofen and/or a salt thereof. By mixing, into the liquid drug that includes dibutylhydroxytoluene and pranoprofen and/or a salt thereof, at least one selected from the group consisting of cromoglycic acid, allantoin, glycyrrhizinic acid, chlorpheniramine, and pharmaceutically acceptable salts of these, and by employing a resin including polybutylene terephthalate as a resin that constitutes an inner wall surface (such as the wall surface of an interior space in a spout portion and/or a lid wall surface facing a spout opening in the spout portion) of an accommodating container, the thermal stability of the dibutylhydroxytoluene in the liquid drug can be increased, adsorption of the dibutylhydroxytoluene to the container can be suppressed, and a decrease in the dibutylhydroxytoluene content over time can be suppressed.

Inventors:
NEMOTO, Fukiko (5-4, Murotani 1-chome, Nishi-ku, Kobe-sh, Hyogo 41, 〒6512241, JP)
NAKASE, Shunsuke (5-4, Murotani 1-chome, Nishi-ku, Kobe-sh, Hyogo 41, 〒6512241, JP)
Application Number:
JP2015/056985
Publication Date:
September 17, 2015
Filing Date:
March 10, 2015
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SENJU PHARMACEUTICAL CO., LTD. (5-8 Hiranomachi 2-chome, Chuo-ku Osaka-sh, Osaka 46, 〒5410046, JP)
International Classes:
A61K31/436; A61J1/05; A61K9/08; A61K47/04; A61K47/10; A61K47/12; A61K47/22; A61P27/02
Domestic Patent References:
WO2013099861A12013-07-04
Foreign References:
JP2006232823A2006-09-07
JP2005336153A2005-12-08
JP2007099697A2007-04-19
JP2011098960A2011-05-19
Attorney, Agent or Firm:
YAMADA, Iichiro et al. (21st Floor, Nakanoshima Intes Bldg. 6-2-40, Nakanoshima, kita-ku, Osaka-sh, Osaka 05, 〒5300005, JP)
Download PDF: