Title:
METHOD OF STABILIZING MACROLIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2005/073223
Kind Code:
A1
Abstract:
A method of stabilizing a macrolide compound and a process for efficiently producing the compound. The method, which is for stabilizing a 12-membered cyclic macrolide compound, e.g., that represented by the formula (I), comprises causing the compound to coexist with a cyclodextrin. The process, which is for producing the macrolide compound, comprises causing a cyclodextrin to be present in a culture medium containing an actinomyces having the ability to produce the macrolide compound. (I)
Inventors:
ISHIHARA HIROSHI
TAKEDA SUSUMU
YAMADA TOMONARI
ASAHI YOSHIAKI
TAKEDA SUSUMU
YAMADA TOMONARI
ASAHI YOSHIAKI
Application Number:
PCT/JP2005/001637
Publication Date:
August 11, 2005
Filing Date:
January 28, 2005
Export Citation:
Assignee:
EISAI CO LTD (JP)
MERCIAN CORP
ISHIHARA HIROSHI
TAKEDA SUSUMU
YAMADA TOMONARI
ASAHI YOSHIAKI
MERCIAN CORP
ISHIHARA HIROSHI
TAKEDA SUSUMU
YAMADA TOMONARI
ASAHI YOSHIAKI
International Classes:
C07D313/00; C07D407/06; C12N1/20; C12P17/08; C12P17/16; C08B37/16; (IPC1-7): C07D407/06; C07D313/00; C12P17/08
Domestic Patent References:
| WO2002060890A1 | 2002-08-08 |
Foreign References:
| JPH04352783A | 1992-12-07 | |||
| JPH11509223A | 1999-08-17 | |||
| JP2002502810A | 2002-01-29 | |||
| JPH0948737A | 1997-02-18 | |||
| JPS58179496A | 1983-10-20 |
Other References:
See also references of EP 1710244A4
Attorney, Agent or Firm:
Furuya, Satoshi (2-17-8 Nihonbashi-Hamacho, Chuo-k, Tokyo 07, JP)
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