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Title:
METHOD FOR STEREOSELECTIVELY PRODUCING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2019/070059
Kind Code:
A1
Abstract:
The present invention provides a commercially applicable method for producing an intermediate of a substituted polycyclic pyridone derivative exhibiting cap-dependent endonuclease inhibitory activity. In the production method shown in the reaction formula (in the formula, the symbols are as defined in the description), by means of an intramolecular cyclisation reaction in which the stereochemistry of a compound shown in formula (III) or formula (VI) is controlled, a compound shown in formula (IV) and including an eliminable functional group on an asymmetric carbon is obtained, and said eliminable functional group is eliminated, whereby an optically active substituted 3-ring pyridone derivative shown in formula (VII) is highly enantioselectively obtained in a high yield.

Inventors:
OKAMOTO, Kazuya (1-1, Futaba-cho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
UENO, Tatsuhiko (1-1, Futaba-cho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
HATO, Yoshio (1-1, Futaba-cho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
HAKOGI, Toshikazu (1-3, Kuise Terajima 2-chome, Amagasaki-sh, Hyogo 13, 〒6600813, JP)
MAJIMA, Shohei (1-3, Kuise Terajima 2-chome, Amagasaki-sh, Hyogo 13, 〒6600813, JP)
Application Number:
JP2018/037390
Publication Date:
April 11, 2019
Filing Date:
October 05, 2018
Export Citation:
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Assignee:
SHIONOGI & CO., LTD. (1-8 Doshomachi 3-chome, Chuo-ku Osaka-sh, Osaka 45, 〒5410045, JP)
International Classes:
C07D498/14; C07D213/89; C07D401/12
Domestic Patent References:
WO2016175224A12016-11-03
WO2017104691A12017-06-22
WO2018030463A12018-02-15
Attorney, Agent or Firm:
YAMAO, Norihito et al. (AOYAMA & PARTNERS, Umeda Hankyu Bldg. Office Tower 8-1, Kakuda-cho, Kita-ku, Osaka-sh, Osaka 17, 〒5300017, JP)
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