METHOD FOR STUDY, DETERMINATION OR EVALUATION BY GENE EXPRESSION ANALYSIS

WIPO Patent Application WO/2008/029838

A1

Disclosed is a method for the study, determination or evaluation of a disease condition in a SART-stressed animal or a pharmacological activity of a substance of interest (e.g., an analgetic activity, an autonomic imbalance-ameliorating activity, an anti-stress activity) on the animal at the gene level. A disease condition in a SART-stressed animal or a pharmacological activity of a substance of interest (particularly, an analgetic activity, an autonomic imbalance-ameliorating activity, an anti-stress activity) on the animal can be studied, determined or evaluated at the gene level by administering the substance to the SART-stressed animal and comprehensively analyzing the change in gene expression in a neural tissue of the animal. It becomes possible to search for a substance effective for a painful disease, a stress-induced disease or autonomic imbalance, to determine/evaluate the effect of the substance, or to analyze a target gene for the substance.

NAIKI, Mitsuru (Institute of Bio-Active Science, 442-1, Kawakitayama, Kinashi, Kato-sh, Hyogo 61, 6731461, JP)
内木 充 (〒61 兵庫県加東市木梨川北山４４２番１号 日本臓器製薬株式会社 生物活性科学研究所内 Hyogo, 6731461, JP)

JP2007/067293

March 13, 2008

September 05, 2007

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NIPPON ZOKI PHARMACEUTICAL CO., LTD. (1-2 Hiranomachi 2-chome, Chuo-ku Osaka-sh, Osaka 46, 5410046, JP)
日本臓器製薬株式会社 (〒46 大阪府大阪市中央区平野町２丁目１番２号 Osaka, 5410046, JP)
NAIKI, Mitsuru (Institute of Bio-Active Science, 442-1, Kawakitayama, Kinashi, Kato-sh, Hyogo 61, 6731461, JP)

C12Q1/68; G01N33/15; G01N33/50; C12N15/12

FUJII, Ikuro (NIPPON ZOKI PHARMACEUTICAL CO. LTD, Legal Management Division, 1-2, Hiranomachi 2-chome, Chuo-ku,Osaka-sh, Osaka 46, 5410046, JP)

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