Title:
METHOD FOR STUDY, DETERMINATION OR EVALUATION BY GENE EXPRESSION ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2008/029838
Kind Code:
A1
Abstract:
Disclosed is a method for the study, determination or evaluation of a disease condition in a SART-stressed animal or a pharmacological activity of a substance of interest (e.g., an analgetic activity, an autonomic imbalance-ameliorating activity, an anti-stress activity) on the animal at the gene level. A disease condition in a SART-stressed animal or a pharmacological activity of a substance of interest (particularly, an analgetic activity, an autonomic imbalance-ameliorating activity, an anti-stress activity) on the animal can be studied, determined or evaluated at the gene level by administering the substance to the SART-stressed animal and comprehensively analyzing the change in gene expression in a neural tissue of the animal. It becomes possible to search for a substance effective for a painful disease, a stress-induced disease or autonomic imbalance, to determine/evaluate the effect of the substance, or to analyze a target gene for the substance.
Inventors:
NAIKI MITSURU (JP)
OKADA TOMOYUKI (JP)
OKADA TOMOYUKI (JP)
Application Number:
PCT/JP2007/067293
Publication Date:
March 13, 2008
Filing Date:
September 05, 2007
Export Citation:
Assignee:
NIPPON ZOKI PHARMACEUTICAL CO (JP)
NAIKI MITSURU (JP)
OKADA TOMOYUKI (JP)
NAIKI MITSURU (JP)
OKADA TOMOYUKI (JP)
International Classes:
C12Q1/68; A61K35/36; A61K35/76; A61P25/00; A61P25/04; A61P25/18; C12Q1/6883; G01N33/15; G01N33/50; C12N15/12
Domestic Patent References:
| WO2004039383A1 | 2004-05-13 |
Other References:
NAMIMATSU A. ET AL.: "SART stress Dobutsu no Seiri Kino Ijo ni Taisuru vaccinia birus Sesshu Ieusagi Ensho Hifu Chushutsueki no Keiko Toyo ni yoru Bogyo Koka", PHARMACOMETRICS, vol. 32, no. 3, 1986, pages 599 - 614, XP003021664
KURE K. ET AL.: "Vaccinia Virus Sesshu Ieusagi Ensho Hifu Chushutsu no Chintsu Sayo", CLINICAL REPORT, vol. 15, no. 5, 1981, pages 2459 - 2470, XP003021665
KITA T. ET AL.: "Mouse ni Okeru Neurotropin no Chintsu Koka to SART Stress Mouse ni Okeru Yakubutsu no Chintsu Sayo", FOLIA PHARMACOL. JAPON, vol. 72, 1976, pages 573 - 584, XP003021666
NIHON BIO INFORMATICS GAKKAI: "Bio Informatics Jiten", 1 July 2006, KYORITSU SHUPPAN CO., LTD., pages: 362 - 364, XP003021678
SASAKI H. ET AL.: "DNA Chip Jikken Maruwakari", 2004, KABUSHIKI KAISHA YODOSHA, article "Experimental Medicine separate volume", XP003021679
KITA ET AL., FOLIA PHARMACOLOGICA JAPONICA, vol. 71, 1975, pages 195
KISO TO RINSHO, vol. 15, no. 5, 1981, pages 2459
OUYOU YAKURI, vol. 32, no. 3, 1986, pages 599
See also references of EP 2075341A4
KURE K. ET AL.: "Vaccinia Virus Sesshu Ieusagi Ensho Hifu Chushutsu no Chintsu Sayo", CLINICAL REPORT, vol. 15, no. 5, 1981, pages 2459 - 2470, XP003021665
KITA T. ET AL.: "Mouse ni Okeru Neurotropin no Chintsu Koka to SART Stress Mouse ni Okeru Yakubutsu no Chintsu Sayo", FOLIA PHARMACOL. JAPON, vol. 72, 1976, pages 573 - 584, XP003021666
NIHON BIO INFORMATICS GAKKAI: "Bio Informatics Jiten", 1 July 2006, KYORITSU SHUPPAN CO., LTD., pages: 362 - 364, XP003021678
SASAKI H. ET AL.: "DNA Chip Jikken Maruwakari", 2004, KABUSHIKI KAISHA YODOSHA, article "Experimental Medicine separate volume", XP003021679
KITA ET AL., FOLIA PHARMACOLOGICA JAPONICA, vol. 71, 1975, pages 195
KISO TO RINSHO, vol. 15, no. 5, 1981, pages 2459
OUYOU YAKURI, vol. 32, no. 3, 1986, pages 599
See also references of EP 2075341A4
Attorney, Agent or Firm:
FUJII, Ikuro (Legal Management Division, 1-2, Hiranomachi 2-chome, Chuo-ku,Osaka-sh, Osaka 46, JP)
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