Title:
METHOD OF TREATING/PREVENTING SUBSTANCE ABUSE USING 1-ALKYL-5(SUBSTITUTED OXY)-2-AMINOTETRALINS
Document Type and Number:
WIPO Patent Application WO1992019234
Kind Code:
A3
Abstract:
Disclosed is a method of caring for human who is or was dependent on a substance which comprises administering to the individual an effective amount of an aminotetralin of formula (I) where caring is (1) treating an individual who is dependent (either physically or psychologically) on a substance, (2) preventing an individual who is recreationally using, but not dependent upon a substance, from becoming dependent on the same or other substances of abuse, (3) preventing an individual who was previously, but not now, dependent from again becoming dependent on a substance, (4) preventing individuals who have no history of substance abuse but from whose life styles and activities clinicians believe are at risk of using substance for recreational purposes and/or becoming dependent on various substances.
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Inventors:
PIERCEY MONTFORD F (US)
Application Number:
PCT/US1992/002808
Publication Date:
January 07, 1993
Filing Date:
April 13, 1992
Export Citation:
Assignee:
UPJOHN CO (US)
International Classes:
A61K31/13; A61P25/30; (IPC1-7): A61K31/13
Foreign References:
| EP0064964A1 | 1982-11-17 | |||
| US4994486A | 1991-02-19 | |||
| US4935429A | 1990-06-19 | |||
| US4800204A | 1989-01-24 |
Other References:
Journal of Neural Transmission, vol. 65, no. 1, 1986, Springer-Verlag, K. SVENSSON et al.: "(+)-UH 232 and (+)-UH 242: novel stereoselective dopamine receptor antagonists with preferential action on autoreceptors", pages 1-27, see whole document
European Journal of Pharmacology, vol. 182, no. 2, 3 July 1990, Elsevier Science Publishers B.V. (Biomedical Division), M.F. PIERCEY et al.: "Electrophysiological effects of dopamine autoreceptor antagonists, (+)-AJ 76 and (+)-UH 232", pages 219-226, see whole document
Alcohol, vol. 7, no. 3, May/June 1990, Pergamon Press plc, (US), G.F. KOOB et al.: "Pharmacology of drug self-administration", pages 193-197, see page 195
J. Med. Chem., vol. 25, no. 3, 1982, American Chemical Society, D.S. FRIES et al.: "Aminotetralins as narcotic antagonists. 2. Synthesis and opiate-related activity of 1-phenyl-3-aminotetralins", pages 216-220, see whole document
Psychopharmacology, vol. 107, no. 1, May 1992, Springer-Verlag, (Berlin, DE), P.M. CALLAHAN et al.: "Effects of the putative dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 on the discriminative stimulus properties of cocaine", pages 73-77, see whole document
European Journal of Pharmacology, vol. 182, no. 2, 3 July 1990, Elsevier Science Publishers B.V. (Biomedical Division), M.F. PIERCEY et al.: "Electrophysiological effects of dopamine autoreceptor antagonists, (+)-AJ 76 and (+)-UH 232", pages 219-226, see whole document
Alcohol, vol. 7, no. 3, May/June 1990, Pergamon Press plc, (US), G.F. KOOB et al.: "Pharmacology of drug self-administration", pages 193-197, see page 195
J. Med. Chem., vol. 25, no. 3, 1982, American Chemical Society, D.S. FRIES et al.: "Aminotetralins as narcotic antagonists. 2. Synthesis and opiate-related activity of 1-phenyl-3-aminotetralins", pages 216-220, see whole document
Psychopharmacology, vol. 107, no. 1, May 1992, Springer-Verlag, (Berlin, DE), P.M. CALLAHAN et al.: "Effects of the putative dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 on the discriminative stimulus properties of cocaine", pages 73-77, see whole document
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