Title:
METHOD OF SUPPRESSING FORMATION OF PHOTOCROSSLINK, AND PHOTOREACTIVE NUCLEIC ACID IN WHICH AUTO-CROSSLINK FORMATION IS SUPPRESSED
Document Type and Number:
WIPO Patent Application WO/2015/064718
Kind Code:
A8
Abstract:
Provided is a means for preventing the inactivation of a photoresponsive nucleic acid probe by suppressing the formation of a photocrosslink between a photoresponsive base having a photocrosslinkable vinyl structure and a photocrosslinkable thymine (T) or uracil (U) base, by substituting with an R group (R being -CN or -CO-R1, where R1 is a saturated or unsaturated straight-chain or branched cyclic or non-cyclic C1-12 hydrocarbon group) the 5 position of a pyrimidine ring of the thymine (T) or uracil (U) base which is photocrosslinkable with the photoresponsive base having a photocrosslinkable vinyl structure.
Inventors:
FUJIMOTO KENZO (JP)
NAKAMURA SHIGETAKA (JP)
NAKAMURA SHIGETAKA (JP)
Application Number:
PCT/JP2014/078980
Publication Date:
July 23, 2015
Filing Date:
October 30, 2014
Export Citation:
Assignee:
JAPAN ADV INST SCIENCE & TECH (JP)
International Classes:
C07H19/073; C07H21/04; C12N15/09
Attorney, Agent or Firm:
AXIS PATENT INTERNATIONAL et al. (6-2 Shimbashi 2-Chome Minato-k, Tokyo 04, JP)
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