Title:
METHOD FOR SUPPRESSING INCREASE IN HEART RATE DURING EXERCISE, AND COMPOSITION FOR SUPPRESSING INCREASE IN HEART RATE
Document Type and Number:
WIPO Patent Application WO/2016/182053
Kind Code:
A1
Abstract:
Provided is a method in which a casein hydrolysate, which is obtained by hydrolyzing animal milk casein, contains free amino acids and peptides, and has an average chain length of not more than 2.1 in terms of the number of amino acid residues, or a composition containing a mixture of the free amino acids and peptides contained in the hydrolysate is orally administered before starting exercise, during exercise, or both before and during exercise. Further provided is a composition for oral administration to be used according to the above-mentioned method, said composition containing, as an active ingredient, the casein hydrolysate, which is obtained by hydrolyzing animal milk casein, contains free amino acids and peptides, and has an average chain length of not more than 2.1 in terms of the number of amino acid residues, or the mixture of the free amino acids and peptides contained in the hydrolysate. Still further provided is the use of the composition for oral administration to suppress an increase in heart rate during exercise.
Inventors:
MIYAZAKI HIDETOSHI (JP)
OHKI KOHJI (JP)
OHKI KOHJI (JP)
Application Number:
PCT/JP2016/064257
Publication Date:
November 17, 2016
Filing Date:
May 13, 2016
Export Citation:
Assignee:
ASAHI CALPIS WELLNESS CO LTD (JP)
International Classes:
A23L33/17; A61K38/00; A61P9/00; A61K38/17
Foreign References:
| JP2007204406A | 2007-08-16 | |||
| JPH02167052A | 1990-06-27 |
Other References:
NAKAMURA H. ET AL.: "Influences of Casein Hydrolysate Ingestion on Cerebral Activity, Autonomic Nerve Activity, and Anxiety.", J. PHYSIOL. ANTHROPOL., vol. 29, no. 3, 2010, pages 103 - 108, XP055328588
MIYAZAKI H. ET AL.: "Milk casein hydrolysate lowered heart rate during downhill walking exercise and muscle damage after that in middle-aged to elderly men.", THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 12TH ASIAN CONGRESS OF NUTRITION, 14 May 2015 (2015-05-14), pages 1 - 8, XP055328593
STAN E. YA. ET AL.: "On heterogeneity and physiological activity of bovine kappa-casein proteolysis products.", VOPROSY PITANIYA, vol. 1, 1988, pages 39 - 43, ISSN: 0042-8833
STAN E. YA. ET AL.: "Isolation amino acid composition and biological effect of peptide bioregulator from bovine kappa casein.", BYULLETEN' EKSPERIMENTAL'NOI BIOLOGII I MEDITSINY, vol. 102, no. 12, 1986, pages 652 - 655, ISSN: 0365-9615
MIYAZAKI H. ET AL.: "Milk casein hydrolysate lowered heart rate during downhill walking exercise and muscle damage after that in middle-aged to elderly men.", THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 12TH ASIAN CONGRESS OF NUTRITION, 14 May 2015 (2015-05-14), pages 1 - 8, XP055328593
STAN E. YA. ET AL.: "On heterogeneity and physiological activity of bovine kappa-casein proteolysis products.", VOPROSY PITANIYA, vol. 1, 1988, pages 39 - 43, ISSN: 0042-8833
STAN E. YA. ET AL.: "Isolation amino acid composition and biological effect of peptide bioregulator from bovine kappa casein.", BYULLETEN' EKSPERIMENTAL'NOI BIOLOGII I MEDITSINY, vol. 102, no. 12, 1986, pages 652 - 655, ISSN: 0365-9615
Attorney, Agent or Firm:
SAKAI Hajime et al. (JP)
Sakai 1 (JP)
Sakai 1 (JP)
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