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Title:
METHOD FOR SUPPRESSING RAS ACTIVATED IN CELL BY USING ANTIBODY HAVING CYTOPLASM PENETRATION CAPACITY AND COMPLETE IMMUNOGLOBULIN FORM, AND USE FOR SAME
Document Type and Number:
WIPO Patent Application WO/2016/013871
Kind Code:
A1
Abstract:
The present invention relates to a method for suppressing RAS activated in a cell by using an antibody having cytoplasm penetration capacity and complete immunoglobulin form. In addition, the present invention relates to a heavy chain variable region (VH) that induces bonding, with RAS activated in a cytoplasm, by means of the active penetration, by an antibody having complete immunoglobulin form, of the cytoplasm of a living cell by endocytosis and endosomal escape, and an antibody comprising same. Also, the present invention relates to a method for treating cancer or tumors or for inhibiting the growth of cancer or tumor cells by using the antibody. The present invention also relates to a method for screening a heavy chain variable region that specifically bonds to RAS in a cytoplasm. The present invention also relates to a bioactive molecule fused to the antibody. The present invention also relates to a composition for preventing, treating or diagnosing cancer, comprising the antibody or the bioactive molecule fused to same. The present invention also relates to a polynucleotide that codes a light chain variable region and the antibody.

Inventors:
KIM YONG SUNG (KR)
CHOI DONG KI (KR)
SHIN SEUNG MIN (KR)
KIM SUNG HOON (KR)
Application Number:
KR2015/007627
Publication Date:
January 28, 2016
Filing Date:
July 22, 2015
Export Citation:
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Assignee:
AJOU UNIV IND ACAD COOP FOUND (KR)
MEDICINAL BIOCONVERGENCE RES CT (KR)
International Classes:
A61K39/395; A61K47/48; A61P35/00; C07K16/32; C07K16/46; C12N15/13; G01N33/53
Domestic Patent References:
WO2003077945A12003-09-25
Foreign References:
US20050288492A12005-12-29
US20140179543A12014-06-26
Other References:
TANAKA, T. ET AL.: "Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation", EMBO J., vol. 22, no. 5, 2003, pages 1025 - 1035, XP008028868
MARSCHALL, A. L. J. ET AL.: "Targeting antibodies to the cytoplasm", MABS, vol. 3, no. 1, February 2011 (2011-02-01), pages 3 - 16
See also references of EP 3173099A4
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉ€μˆœμ›… (KR)
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