Title:
METHOD FOR THE SYNTHESIS OF HUPERZINE A AND ANALOGS THEREOF AND COMPOUNDS USEFUL THEREIN
Document Type and Number:
WIPO Patent Application WO1990009993
Kind Code:
A3
Abstract:
The present invention relates to racemic huperzine A, a pharmaceutical composition comprising huperzine A, its use as a medicament and for the manufacture of a medicament for the inhibition of the cholesterase enzymes in a mammal.
Inventors:
KOZIKOWSKI ALAN P (US)
XIA YAN (US)
XIA YAN (US)
Application Number:
PCT/US1990/000925
Publication Date:
November 01, 1990
Filing Date:
February 21, 1990
Export Citation:
Assignee:
UNIV PITTSBURGH (US)
International Classes:
A61P43/00; C07D215/48; C07D221/04; C07D221/22; (IPC1-7): C07D/
Other References:
Acta Pharmaceutica Sinica Vol. 22, #11, CHEN, et al. "The Effect of Fordine on Learning and Memory in Rats" pp. 801-806 1987 see Abstract.
Acta Pharmacologica Sinica Vol. 9, #3, WANG, et al. "Pharmacokinetics of huperzine A in rats and mice" pp. 193-196 1988 see Abstract.
Canadian Journal of Chemistry, Vol. 64, LIU, et al. "The structures of huperzine A and B...." pp. 837-839 1986 see full document.
Canadian Journal of Chemistry Vol. 62, GRAVEL, et al. "Total regiospecific synthesis of the sclagine tricyclic ring system" pp. 2945-2847 1984 see synthesis diagrams.
Heterocycles Vol. 21, No. 1, 1984 KENDE, et al. "New tactics in Heterocyclic Synthesis" pp. 91-106. See bottom of p. 101-p. 104.
CHEMICAL ABSTRACTS Vol. 101, 1984 of Tai-Wan Yao Hsueh Tsu Chih Vol. 36, 1984 CHEN, et al. "Studies on the bioactive lycopodium alkaloid-the structure and activity of isoselagine from lycopodium serratum var. longipetiolatum". Abstract No. 101:143940W.
CHEMICAL ABSTRACTS Vol. 86, 1977 of Bull. Soc. Chim. Belg. Vol. 85, No. 8 1976 NYAMBO, et al. "Alkaloids of lycopodium gnidioides and lycopodium verticillatum" Abstract No. 86:90108u.
CHEMICAL ABSTRACTS Vol. 106, 1987 of Zhongguo Yaoli Xuebau Vol. 7 No. 6 1986 TANG, et al. "Effects of huperzine A on learning and retrieval process of discrimination performance in rats" Abstracts No. 106:12878n.
CHEMICAL ABSTRACTS Vol. 107, 1987 of Huaxue Xuebao Vol. 44 No. 10 1986 LIU, et al. "Chemistry of huperzine A B" Abstract No. 107:115821p see full Abstract.
Acta Pharmacologica Sinica Vol. 9, #3, WANG, et al. "Pharmacokinetics of huperzine A in rats and mice" pp. 193-196 1988 see Abstract.
Canadian Journal of Chemistry, Vol. 64, LIU, et al. "The structures of huperzine A and B...." pp. 837-839 1986 see full document.
Canadian Journal of Chemistry Vol. 62, GRAVEL, et al. "Total regiospecific synthesis of the sclagine tricyclic ring system" pp. 2945-2847 1984 see synthesis diagrams.
Heterocycles Vol. 21, No. 1, 1984 KENDE, et al. "New tactics in Heterocyclic Synthesis" pp. 91-106. See bottom of p. 101-p. 104.
CHEMICAL ABSTRACTS Vol. 101, 1984 of Tai-Wan Yao Hsueh Tsu Chih Vol. 36, 1984 CHEN, et al. "Studies on the bioactive lycopodium alkaloid-the structure and activity of isoselagine from lycopodium serratum var. longipetiolatum". Abstract No. 101:143940W.
CHEMICAL ABSTRACTS Vol. 86, 1977 of Bull. Soc. Chim. Belg. Vol. 85, No. 8 1976 NYAMBO, et al. "Alkaloids of lycopodium gnidioides and lycopodium verticillatum" Abstract No. 86:90108u.
CHEMICAL ABSTRACTS Vol. 106, 1987 of Zhongguo Yaoli Xuebau Vol. 7 No. 6 1986 TANG, et al. "Effects of huperzine A on learning and retrieval process of discrimination performance in rats" Abstracts No. 106:12878n.
CHEMICAL ABSTRACTS Vol. 107, 1987 of Huaxue Xuebao Vol. 44 No. 10 1986 LIU, et al. "Chemistry of huperzine A B" Abstract No. 107:115821p see full Abstract.
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