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Title:
METHOD FOR SYNTHESISING 4-PIPERIDIN-4-YL-BENZENE-1,3-DIOL AND THE SALTS OF SAME AND NOVEL COMPOUND TERT-BUTYL 4-(2,4-DIHYDROXY-PHENYL)-4-HYDROXY-PIPERIDINE-1-CARBOXYLATE
Document Type and Number:
WIPO Patent Application WO/2014/125233
Kind Code:
A3
Abstract:
The present invention relates to a method for synthesising 4-piperidin-4-yl-benzene-1,3-diol of the following formula (I): and the pharmaceutically acceptable salts thereof, as well as to tert-butyl 4-(2.4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate as a novel intermediate compound.

Inventors:
BOITEAU, Jean-Guy (136 B chemin du Ribas, Valbonne, F-06560, FR)
MUSICKI, Branislav (15 rue Verdi, bâtiment B, Nice, F-06000, FR)
Application Number:
FR2014/050314
Publication Date:
October 09, 2014
Filing Date:
February 14, 2014
Export Citation:
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Assignee:
GALDERMA RESEARCH & DEVELOPMENT (2400 Route des Colles, Les Templiers, Biot, F-06410, FR)
International Classes:
C07D211/22; C07B35/02; C07D211/52
Domestic Patent References:
WO2012122391A12012-09-13
WO2011070080A12011-06-16
WO2011033255A12011-03-24
WO2010081904A12010-07-22
WO2010063774A12010-06-10
WO2009098576A12009-08-13
WO2007092681A22007-08-16
WO2005121087A12005-12-22
WO2004010943A22004-02-05
Other References:
PETTERSSON, FREDRIK ET AL: "Synthesis and Evaluation of a Set of 4-Phenylpiperidines and 4-Phenylpiperazines as D2 Receptor Ligands and the Discovery of the Dopaminergic Stabilizer 4-[3-(Methylsulfonyl)phenyl]-1- propylpiperidine (Huntexil, Pridopidine, ACR16)", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 6, 2010, pages 2510 - 2520, XP002728055, DOI: 10.1021/JM901689V
CHIU, GEORGE ET AL: "(Phenylpiperidinyl)cyclohexylsulfonamides: Development of .alpha.1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 14, 2007, pages 3930 - 3934, XP002728056, DOI: 10.1016/J.BMCL.2007.04.098
Attorney, Agent or Firm:
TEZIER HERMAN, Béatrice et al. (Becker & Associes, 25 rue Louis le Grand, Paris, F-75002, FR)
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