Title:
METHOD OF SYNTHESIZING 3-HALO-D-ALANINE METHYL ESTER OR ACID SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/155596
Kind Code:
A1
Abstract:
Disclosed is a method of synthesizing a 3-halo-D-alanine methyl ester or an acid salt thereof. By reacting a D-serine methyl ester or an acid salt thereof and a halogenation reagent in an organic solvent, the method prepares a 3-halo-D-alanine methyl ester or an acid salt thereof. The compound is an important intermediate for preparing a D-cycloserine. The method and process employed in the present invention are easy to operate and highly safe, require a moderate reaction condition, have a high yield, and are low in cost, and reduce waste acid generation considerably and are suitable for industrial production.
Inventors:
FU DEJIN (CN)
WU ZHIXIAN (CN)
YANG YONG (CN)
WEN WEIJIANG (CN)
WU ZHIXIAN (CN)
YANG YONG (CN)
WEN WEIJIANG (CN)
Application Number:
PCT/CN2016/077537
Publication Date:
October 06, 2016
Filing Date:
March 28, 2016
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
International Classes:
C07C227/16; C07C229/20
Foreign References:
| CN101550100A | 2009-10-07 | |||
| CN104003894A | 2014-08-27 | |||
| CN103288710A | 2013-09-11 | |||
| CN105209470A | 2015-12-30 |
Other References:
KIM, HEE-KWON ET AL.: "Simple and efficient synthetic routes to D-cycloserine", TETRAHEDRON LETTERS, vol. 53, no. 13, 28 January 2012 (2012-01-28), pages 1668 - 1670, XP028459580
NAGLE, ADVAIT S. ET AL.: "Efficient synthesis of beta -amino bromides", TETRAHEDRON LETTERS, vol. 41, no. 17, 31 December 2000 (2000-12-31), pages 3011 - 3014, XP004196714, DOI: doi:10.1016/S0040-4039(00)00330-0
NAGLE, ADVAIT S. ET AL.: "Efficient synthesis of beta -amino bromides", TETRAHEDRON LETTERS, vol. 41, no. 17, 31 December 2000 (2000-12-31), pages 3011 - 3014, XP004196714, DOI: doi:10.1016/S0040-4039(00)00330-0
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
上海弼兴律师事务所 (CN)
上海弼兴律师事务所 (CN)
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