Title:
METHOD FOR SYNTHESIZING 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2022/174524
Kind Code:
A1
Abstract:
A method for synthesizing a 3',5'-dichloro-2,2,2-trifluoroacetophenone derivative. The method specifically comprises the following steps: S1, preparing a Grignard reagent from a 1-bromo-3,5-dichloro-4-substituted compound by means of a grignardization reagent; and S2, reacting the Grignard reagent and a trifluoroacetyl compound, and then subjecting same to an acid treatment, so as to obtain a 3',5'-dichloro-2,2,2-trifluoroacetophenone derivative. The technical solution used in the present application has mild reaction conditions, involves readily available raw materials and has a relatively high yield, which helps to save the production cost of enterprises and is suitable for large-scale production.
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Inventors:
ZHANG LINGXIAO (CN)
CAI GANGHUA (CN)
TANG HONGYUAN (CN)
CHENG JINTAO (CN)
CAI GANGHUA (CN)
TANG HONGYUAN (CN)
CHENG JINTAO (CN)
Application Number:
PCT/CN2021/093761
Publication Date:
August 25, 2022
Filing Date:
May 14, 2021
Export Citation:
Assignee:
TAIZHOU ABSOBIOTEC CO LTD (CN)
ZHEJIANG JIANGBEI NANHAI PHARMACEUTICAL CO LTD (CN)
ZHEJIANG JIANGBEI NANHAI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C45/45; C07C49/80
Domestic Patent References:
| WO2017201134A1 | 2017-11-23 |
Foreign References:
| CN101990530A | 2011-03-23 | |||
| CN112028752A | 2020-12-04 | |||
| CN106795082A | 2017-05-31 | |||
| CN108047019A | 2018-05-18 | |||
| CN103224447A | 2013-07-31 | |||
| CN110204450A | 2019-09-06 | |||
| CN102414202A | 2012-04-11 | |||
| JP2008133242A | 2008-06-12 | |||
| CN112110790A | 2020-12-22 | |||
| CN106518636A | 2017-03-22 |
Attorney, Agent or Firm:
BEIJING WEIZHENG PATENT AGENCY CO., LTD. (CN)
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