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Title:
METHOD FOR SYNTHESIZING 5,8-DIAMINO-3,4-DIHYDRO-2H-1-NAPHTHALENONE AND INTERMEDIATE COMPOUND USED THEREIN
Document Type and Number:
WIPO Patent Application WO/2023/020531
Kind Code:
A1
Abstract:
A method for synthesizing 5,8-diamino-3,4-dihydro-2H-1-naphthalenone (compound I), which method comprises: subjecting 2,5-diprotected aminophenylbutyric acid to the Friedel-Crafts reaction for ring closure, and then removing a protecting group on the amino group to obtain compound I.

Inventors:
XU HUI (CN)
ZHOU WEI (CN)
WANG ZHENZHEN (CN)
TAN XIAODING (CN)
Application Number:
PCT/CN2022/112985
Publication Date:
February 23, 2023
Filing Date:
August 17, 2022
Export Citation:
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Assignee:
JIANGSU MABWELL HEALTH PHARMACEUTICAL R&D CO LTD (CN)
MABWELL SHANGHAI BIOSCIENCE CO LTD (CN)
International Classes:
C07C13/28; C07C49/613; C07C233/15; C07D491/22
Domestic Patent References:
WO2020200880A12020-10-08
WO2020200880A12020-10-08
Foreign References:
CN111065621A2020-04-24
CN112300019A2021-02-02
EP0495432A11992-07-22
JPH0687746A1994-03-29
CN1175943A1998-03-11
Other References:
DATABASE REGISTRY ANONYMOUS : "Benzenebutanoic acid, 5-(acetylamino)-2-[[(9H-fluoren-9- ylmethoxy)carbonyl]amino]-(CA INDEX NAME)", XP093037180, retrieved from STN
SUGIMORI, MASAMICHI ET AL.: "Synthesis and Antitumor Activity of Ring A- and F-Modified Hexacyclic Camptothecin Analogues", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 13, 3 June 1998 (1998-06-03), XP002239569, DOI: 10.1021/jm970765q
JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 13, 1998, pages 2308 - 2318
Attorney, Agent or Firm:
LEADING INTELLECTUAL PROPERTY FIRM (CN)
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