Title:
METHOD FOR SYNTHESIZING BENZOFURAN DERIVATIVE BY MEANS OF NON-METAL LEWIS ACID CATALYZING ADDITION OF C-O BOND WITHIN OLEFIN MOLECULE
Document Type and Number:
WIPO Patent Application WO/2019/214749
Kind Code:
A1
Abstract:
A method for synthesizing a benzofuran derivative by means of a non-metal Lewis acid catalyzing the addition of a C-O bond within an olefin molecule, comprising the following steps: step one, preparing an olefin: using a phenol derivative as a raw material and performing three steps of reactions to obtain an olefin that acts as a reaction substrate; step two, adding a non-metal Lewis acid and toluene into the reaction substrate prepared in step one to obtain a benzofuran derivative by means of a reaction. The reaction uses a non-metal Lewis acid as a catalyst during a reaction process, which prevents a residual metal catalyst from contaminating a product and also eliminates cumbersome post-treatment.
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Inventors:
ZHAO JIYANG (CN)
Application Number:
PCT/CN2019/087153
Publication Date:
November 14, 2019
Filing Date:
May 16, 2019
Export Citation:
Assignee:
UNIV NANJING XIAOZHUANG (CN)
International Classes:
C07D307/79; C07D307/81
Domestic Patent References:
| WO2006000902A1 | 2006-01-05 |
Foreign References:
| CN108530405A | 2018-09-14 | |||
| CN102421767A | 2012-04-18 | |||
| EP0345593A1 | 1989-12-13 |
Other References:
KOESTER, DENNIS C. ET AL.: "Intramolecular Oxycyanation of Alkenes by Coope- rative Pd/BPh3 Catalysis", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, no. 15, 1 April 2012 (2012-04-01), pages 6544 - 6547, XP055651416, DOI: 10.1021/ja301375c
NICOLAI, STEFANO ET AL.: "Pd-Catalyzed Intramolecular Oxyalkynylation of Alkenes with Hypervalent Iodine", ORGANIC LETTERS, vol. 12, no. 2, 10 December 2009 (2009-12-10), pages 384 - 387, XP055651422, DOI: 10.1021/ol9027286
ZHAO, JIYANG ET AL.: "An insight into the Lewis acid-catalyzed intramoleculai aminocyanation and oxycyanation of alkenes: a concerted or stepwise mechani- sm", CHEMICAL COMMUNICATIONS, vol. 51, 27 August 2015 (2015-08-27), pages 15450 - 15453, XP055651447, DOI: 10.1039/C5CC06808H
NICOLAI, STEFANO ET AL.: "Pd-Catalyzed Intramolecular Oxyalkynylation of Alkenes with Hypervalent Iodine", ORGANIC LETTERS, vol. 12, no. 2, 10 December 2009 (2009-12-10), pages 384 - 387, XP055651422, DOI: 10.1021/ol9027286
ZHAO, JIYANG ET AL.: "An insight into the Lewis acid-catalyzed intramoleculai aminocyanation and oxycyanation of alkenes: a concerted or stepwise mechani- sm", CHEMICAL COMMUNICATIONS, vol. 51, 27 August 2015 (2015-08-27), pages 15450 - 15453, XP055651447, DOI: 10.1039/C5CC06808H
Attorney, Agent or Firm:
NANJING RUIZHIBO INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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