Title:
METHOD FOR SYNTHESIZING LEVETIRACETAM
Document Type and Number:
WIPO Patent Application WO/2019/028666
Kind Code:
A1
Abstract:
Disclosed is a method for preparing levetiracetam, comprising the following steps: performing resolution under the action of an ester hydrolase using 2-halobutyrate as a raw material to obtain (S)-2-halobutyrate, reacting with 2-pyrrolidinone under the action of an alkaline reagent to produce (S)-α-ethyl-2-oxo-1-pyrrolidine acetate, and performing ammonolysis to obtain levetiracetam. The method has advantages of simple process operation, easily available raw materials, and low environmental pollution and the product has high HPLC purity and optical purity, and therefore the method is very suitable for industrial production.
Inventors:
PAN HONGJIE (CN)
XIAO YANMING (CN)
ZHANG WENLING (CN)
WANG PENG (CN)
XIAO YANMING (CN)
ZHANG WENLING (CN)
WANG PENG (CN)
Application Number:
PCT/CN2017/096397
Publication Date:
February 14, 2019
Filing Date:
August 08, 2017
Export Citation:
Assignee:
ZHEJIANG HUAHAI PHARM CO LTD (CN)
ZHEJIANG HUAHAI ZHICHENG PHARMACEUTICAL CO LTD (CN)
ZHEJIANG HUAHAI ZHICHENG PHARMACEUTICAL CO LTD (CN)
International Classes:
C12N1/20; C07D207/27; C12N11/14
Foreign References:
| EP1419144B1 | 2008-10-08 | |||
| CN105063120A | 2015-11-18 | |||
| CN106591179A | 2017-04-26 |
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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