Title:
METHOD FOR SYNTHESIZING NUCLEIC ACID
Document Type and Number:
WIPO Patent Application WO/2010/150789
Kind Code:
A1
Abstract:
Disclosed is a novel production method for efficiently and easily synthesizing an NC-type nucleoside at a high yield without requiring a step for converting an unnecessary protecting group. Specifically disclosed are a step for inverting a compound represented by formula (I) to give a compound represented by formula (II) or a salt thereof; and a method for producing a compound represented by formula (III) or a salt thereof which comprises the aforesaid step [in these formulae, each symbol has the same meaning as defined in the description].
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Inventors:
MURATA SHUMPEI (JP)
UMEMOTO TADASHI (JP)
MIYATA KENICHI (JP)
HAYASE YOJI (JP)
UMEMOTO TADASHI (JP)
MIYATA KENICHI (JP)
HAYASE YOJI (JP)
Application Number:
PCT/JP2010/060572
Publication Date:
December 29, 2010
Filing Date:
June 22, 2010
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
MURATA SHUMPEI (JP)
UMEMOTO TADASHI (JP)
MIYATA KENICHI (JP)
HAYASE YOJI (JP)
MURATA SHUMPEI (JP)
UMEMOTO TADASHI (JP)
MIYATA KENICHI (JP)
HAYASE YOJI (JP)
International Classes:
C07H19/16; C07H9/04
Domestic Patent References:
| WO2008150729A2 | 2008-12-11 | |||
| WO2005021570A1 | 2005-03-10 | |||
| WO2005021570A1 | 2005-03-10 | |||
| WO2007090071A2 | 2007-08-09 | |||
| WO2001007455A1 | 2001-02-01 | |||
| WO2003068795A1 | 2003-08-21 |
Foreign References:
| US7217895B1 | 2007-05-15 |
Other References:
PRAKASH, T.P. ET AL.: "Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-0,4'-C- aminomethylene bridged nucleoside analogues show improved potency in aminal models", J. MED. CHEM., vol. 53, no. 4, 2010, pages 1636 - 1650, XP008148699
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 57, 1992, pages 553 - 559
TETRAHEDRON, vol. 40, no. 1, 1984, pages 125 - 135
CARBOHYDRATE RESEARCH, vol. 216, 1991, pages 257 - 269
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, 2005, pages 12035 - 12045
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 57, 1992, pages 553 - 559
TETRAHEDRON, vol. 40, no. 1, 1984, pages 125 - 135
CARBOHYDRATE RESEARCH, vol. 216, 1991, pages 257 - 269
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, 2005, pages 12035 - 12045
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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