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Title:
METHOD FOR SYNTHESIZING NUCLEIC ACID
Document Type and Number:
WIPO Patent Application WO/2010/150789
Kind Code:
A1
Abstract:
Disclosed is a novel production method for efficiently and easily synthesizing an NC-type nucleoside at a high yield without requiring a step for converting an unnecessary protecting group. Specifically disclosed are a step for inverting a compound represented by formula (I) to give a compound represented by formula (II) or a salt thereof; and a method for producing a compound represented by formula (III) or a salt thereof which comprises the aforesaid step [in these formulae, each symbol has the same meaning as defined in the description].

Inventors:
MURATA, Shumpei (10 Wadai, Tsukuba-sh, Ibaraki 93, 〒3004293, JP)
村田 俊平 (〒93 茨城県つくば市和台10番地 武田薬品工業株式会社内 Ibaraki, 〒3004293, JP)
UMEMOTO, Tadashi (10 Wadai, Tsukuba-sh, Ibaraki 93, 〒3004293, JP)
梅本 忠士 (〒93 茨城県つくば市和台10番地 武田薬品工業株式会社内 Ibaraki, 〒3004293, JP)
Application Number:
JP2010/060572
Publication Date:
December 29, 2010
Filing Date:
June 22, 2010
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICAL COMPANY LIMITED (1-1 Doshomachi 4-chome, Chuo-ku Osaka-sh, Osaka 45, 〒5410045, JP)
武田薬品工業株式会社 (〒45 大阪府大阪市中央区道修町四丁目1番1号 Osaka, 〒5410045, JP)
MURATA, Shumpei (10 Wadai, Tsukuba-sh, Ibaraki 93, 〒3004293, JP)
村田 俊平 (〒93 茨城県つくば市和台10番地 武田薬品工業株式会社内 Ibaraki, 〒3004293, JP)
UMEMOTO, Tadashi (10 Wadai, Tsukuba-sh, Ibaraki 93, 〒3004293, JP)
International Classes:
C07H19/16; C07H9/04
Domestic Patent References:
WO2008150729A2
WO2005021570A1
WO2005021570A1
WO2007090071A2
WO2001007455A1
WO2003068795A1
Foreign References:
US7217895B1
Other References:
PRAKASH, T.P. ET AL.: 'Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-0,4'-C- aminomethylene bridged nucleoside analogues show improved potency in aminal models' J. MED. CHEM. vol. 53, no. 4, 2010, pages 1636 - 1650, XP008148699
See also references of EP 2447273A1
THE JOURNAL OF ORGANIC CHEMISTRY vol. 57, 1992, pages 553 - 559
TETRAHEDRON vol. 40, no. 1, 1984, pages 125 - 135
CARBOHYDRATE RESEARCH vol. 216, 1991, pages 257 - 269
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY vol. 127, 2005, pages 12035 - 12045
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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