Title:
METHOD FOR SYNTHESIZING AND REFINING 4-FLUOROBENZOYLACETONITRILE
Document Type and Number:
WIPO Patent Application WO/2021/218275
Kind Code:
A1
Abstract:
Disclosed is a method for synthesizing and refining 4-fluorobenzoylacetonitrile. The method comprises the following steps: dissolving malononitrile in a solvent, adding fluorobenzene and trifluoromethanesulfonic acid to react and obtain a 4-fluorobenzoylacetonitrile crude product; adding an alcohol and a small molecular alkane into the 4-fluorobenzoylacetonitrile crude product for recrystallization so as to obtain 4-fluorobenzoylacetonitrile. The method has the advantages of short synthesis steps, safety and simplicity in operation, a high conversion rate and a low cost, and provides a foundation for the development and application of 4-fluorobenzoylacetonitrile.
Inventors:
WANG KAI (CN)
SUN ZHIBIN (CN)
WANG XIANKANG (CN)
SUN ZHIBIN (CN)
WANG XIANKANG (CN)
Application Number:
PCT/CN2021/075371
Publication Date:
November 04, 2021
Filing Date:
February 05, 2021
Export Citation:
Assignee:
NANJING YUANSHU PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07C253/30; C07C253/34; C07C255/40
Foreign References:
| CN105272883A | 2016-01-27 | |||
| CN111233707A | 2020-06-05 | |||
| CN107056653A | 2017-08-18 |
Other References:
BRIAN L. BOOTH AND GHAZI F. M. NOORI: "The Chemistry of Nitrilium Salts. Part 1. Acylation of Phenols and Phenol Ethers with Nitriles and Trifluoromethanesulphonic Acid", J. CHEM. SOC., PERKIN TRANS 1, vol. 12, 1 January 1980 (1980-01-01), pages 2894 - 2900, XP055861751, DOI: 10.1039/P19800002894
EL-KHAWAGA, A.M.: "Triflic acid catalyzed aroylation of arenes with aromatic nitriles", BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, no. 2, 31 December 1987 (1987-12-31), pages 372 - 374, XP009531466, ISSN: 0037-8968
EL-KHAWAGA, A.M.: "Triflic acid catalyzed aroylation of arenes with aromatic nitriles", BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, no. 2, 31 December 1987 (1987-12-31), pages 372 - 374, XP009531466, ISSN: 0037-8968
Attorney, Agent or Firm:
NANJING JUJIANG INTELLECTUAL PROPERTY CO., LTD. (CN)
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