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Title:
METHOD FOR SYNTHESIZING SUCROSE-6-ESTER
Document Type and Number:
WIPO Patent Application WO/2019/223485
Kind Code:
A1
Abstract:
A method for synthesizing sucrose-6-ester. The method comprises: (a) in the presence of a polar aprotic solvent, contacting an organic phosphine compound represented by formula I with sucrose and an organic tin compound; (b) removing water to obtain a reaction liquid containing a tin-sucrose adduct; and (c) contacting the reaction liquid containing the tin-sucrose adduct with an acid anhydride compound to prepare sucrose-6-ester. (Formula I). R1, R2, and R3 in formula I each are linear or branched alkyl containing 1-20 carbon atoms, cycloalkyl containing 3-10 carbon atoms, or aryl containing 6-10 carbon atoms; moreover, the R1, R2, and R3 are identical groups, partially identical groups, or different groups. According to the method, the reaction conversion efficiency and selectivity are greatly improved, and the molar yield of sucrose-6-ester can reach more than 92% and even can reach 95.3%; moreover, it is easy to implement industrial application.

Inventors:
ZHOU YOUGUI (CN)
CAI JIANG (CN)
MA KAIFENG (CN)
WANG YUGANG (CN)
WEI XIAOQIAO (CN)
YANG YUNHAN (CN)
Application Number:
PCT/CN2019/084014
Publication Date:
November 28, 2019
Filing Date:
April 24, 2019
Export Citation:
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Assignee:
SHANDONG NHU FINE CHEMICAL SCIENCE AND TECH COMPANY LTD (CN)
ZHEJIANG NHU CO LTD (CN)
International Classes:
C07H13/04; C07H13/06
Domestic Patent References:
WO2009035503A12009-03-19
Foreign References:
CN108558962A2018-09-21
CN102639550A2012-08-15
CN104098617A2014-10-15
CN101979396A2011-02-23
US5034551A1991-07-23
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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