Title:
METHOD AND SYSTEM FOR MORPHOLOGY BASED MITOSIS IDENTIFICATION AND CLASSIFICATION OF DIGITAL IMAGES
Document Type and Number:
WIPO Patent Application WO2005076197
Kind Code:
A3
Abstract:
A method and system for morphology based mitosis identification and classification of digital images. Luminance parameters such as intensity, etc. from a digital image of a biological sample (e.g., tissue cells) to which a chemical compound (e.g., a marker dye) has been applied are analyzed and corrected if necessary. Morphological parameters (e.g., size, elongation ratio, parallelism, boundary roughness, convex hull shape, etc.) from individual components within the biological sample are analyzed. A medical conclusion (e.g., type and count of mitotic cells) or a life science and biotechnology experiment conclusion is determined from the analyzed luminance and morphological parameters. The method and system may be used to develop applications for automatically obtaining a medical diagnosis (e.g., a carcinoma diagnosis).
Inventors:
GHOLAP ABHIJEET S (US)
GHOLAP GAURI A (US)
RAO C K V (US)
BARSKY SANFORD H (US)
VIPRA MADHURA (IN)
PATIL SUHAS MANMANTRAO (IN)
JADHAV PRITHVIRAJ (US)
ABHYANKAR JAYANT (US)
GHOLAP GAURI A (US)
RAO C K V (US)
BARSKY SANFORD H (US)
VIPRA MADHURA (IN)
PATIL SUHAS MANMANTRAO (IN)
JADHAV PRITHVIRAJ (US)
ABHYANKAR JAYANT (US)
Application Number:
PCT/US2005/003311
Publication Date:
October 27, 2005
Filing Date:
January 31, 2005
Export Citation:
Assignee:
BIOIMAGENE INC (US)
GHOLAP ABHIJEET S (US)
GHOLAP GAURI A (US)
RAO C K V (US)
BARSKY SANFORD H (US)
VIPRA MADHURA (IN)
PATIL SUHAS MANMANTRAO (IN)
JADHAV PRITHVIRAJ (US)
ABHYANKAR JAYANT (US)
GHOLAP ABHIJEET S (US)
GHOLAP GAURI A (US)
RAO C K V (US)
BARSKY SANFORD H (US)
VIPRA MADHURA (IN)
PATIL SUHAS MANMANTRAO (IN)
JADHAV PRITHVIRAJ (US)
ABHYANKAR JAYANT (US)
International Classes:
G06T7/00; G06V10/25; G06V10/26; G06V10/56; G06V10/60; G06V10/82; (IPC1-7): G06T7/00; G06K9/00
Other References:
KATE TEN T K ET AL: "METHOD FOR COUNTING MITOSES BY IMAGE PROCESSING IN FEULGEN STAINED BREAST CANCER SECTIONS", CYTOMETRY, ALAN LISS, NEW YORK, US, vol. 14, 1993, pages 241 - 250, XP009026418, ISSN: 0196-4763
MADACHY R J ET AL: "Image analysis for automatic classification of MITOTIC cervical cells", PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, 4 November 1988 (1988-11-04), pages 372 - 374, XP010074652
DREZET P M L ET AL: "Automatic mitotic index estimation for the prognostication of breast cancer from histology images", IEE COLLOQUIUM INTELLIGENT METHODS IN HEALTHCARE AND MEDICAL APPLICATIONS, 20 October 1998 (1998-10-20), pages 14 - 1, XP006502885
SUNDBLAD LARS-GORAN ET AL: "The use of image analysis and automation for measuring mitotic index in apical conifer mersitems", JOURNAL OF EXPERIMENTAL BOTANY, OXFORD UNIVERSITY PRESS, GB, vol. 49, no. 327, October 1998 (1998-10-01), pages 1749 - 1756, XP002233559, ISSN: 0022-0957
MADACHY R J ET AL: "Image analysis for automatic classification of MITOTIC cervical cells", PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, 4 November 1988 (1988-11-04), pages 372 - 374, XP010074652
DREZET P M L ET AL: "Automatic mitotic index estimation for the prognostication of breast cancer from histology images", IEE COLLOQUIUM INTELLIGENT METHODS IN HEALTHCARE AND MEDICAL APPLICATIONS, 20 October 1998 (1998-10-20), pages 14 - 1, XP006502885
SUNDBLAD LARS-GORAN ET AL: "The use of image analysis and automation for measuring mitotic index in apical conifer mersitems", JOURNAL OF EXPERIMENTAL BOTANY, OXFORD UNIVERSITY PRESS, GB, vol. 49, no. 327, October 1998 (1998-10-01), pages 1749 - 1756, XP002233559, ISSN: 0022-0957
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