Title:
METHOD AND SYSTEM FOR SELF-CALIBRATING MICROFLUIDIC CHIP-BASED DETECTION SYSTEM
Document Type and Number:
WIPO Patent Application WO/2013/007028
Kind Code:
A1
Abstract:
The present invention provides a method for self-calibrating a microfluidic chip-based detection system, comprising the following steps: S1: mixing reference microbeads with known characteristics and an analytical sample uniformly to enter a detection area of a microfluidic chip together; or, S1': separating the reference microbeads with known characteristics from the analytical sample to pass through the detection area of the microfluidic chip separately; S2: allowing only one reference microbead or one particle of the analytical sample to pass through a detection channel of the detection area at a time, and detecting a signal generated by the reference microbead or the analytical sample by a sensor at the detection area; and S3: comparing the known characteristics of the reference microbead with a detection result, determining a calibration factor, and calibrating the detection area of the microfluidic chip and the detection result of the analytical sample. The present invention further provides a corresponding system. The implementation of the method and the system provided in the present invention has simple operation and enables more accurate detection of the analytical sample by the microfluidic chip.
Inventors:
LIU MULONG (CN)
GUO YONGCHAO (CN)
WANG YANPING (CN)
GUO YONGCHAO (CN)
WANG YANPING (CN)
Application Number:
PCT/CN2011/077131
Publication Date:
January 17, 2013
Filing Date:
July 14, 2011
Export Citation:
Assignee:
SHENZHEN SYDSCI TECHNOLOGY CO LTD (CN)
LIU MULONG (CN)
GUO YONGCHAO (CN)
WANG YANPING (CN)
LIU MULONG (CN)
GUO YONGCHAO (CN)
WANG YANPING (CN)
International Classes:
G01N35/00; B01L3/00
Domestic Patent References:
| WO2000070080A1 | 2000-11-23 |
Foreign References:
| CN1675546A | 2005-09-28 | |||
| CN101923036A | 2010-12-22 | |||
| CN101400445A | 2009-04-01 | |||
| CN1323393A | 2001-11-21 | |||
| CN101726578A | 2010-06-09 | |||
| CN102007395A | 2011-04-06 | |||
| US6582963B1 | 2003-06-24 | |||
| US20050114041A1 | 2005-05-26 |
Attorney, Agent or Firm:
SHENZHEN STANDARD PATENT & TRADEMARK AGENT LTD. (CN)
深圳市顺天达专利商标代理有限公司 (CN)
深圳市顺天达专利商标代理有限公司 (CN)
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