Title:
METHOD AND SYSTEM FOR SYNTHESIZING OLIGONUCLEOTIDES USING NUCLEOTIDE-SPECIFIC DISPENSING BARS
Document Type and Number:
WIPO Patent Application WO1998034091
Kind Code:
A3
Abstract:
A plurality of oligonucleotides are synthesized at a plurality of locations on a substrate (10) using a plurality of dispensing bars (12). Each of the plurality of dispensing bars (12) has a respective plurality of dispensing heads arranged along a respective axis. Each of the plurality of dispensing bars (12) is operative to selectively deposit a volume of a respective one of a plurality of nucleotide bases in any of a row of locations. A positioning mechanism (52) positions the substrate (10) with respect to the plurality of dispensing bars (12). A controller (56) controls the plurality of dispensing bars (12) and the positioning mechanism (52) so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide. 00000
Inventors:
ACKLEY RICHARD (US)
SHIEH CHAN-LONG (US)
HARVEY THOMAS B III (US)
SHIEH CHAN-LONG (US)
HARVEY THOMAS B III (US)
Application Number:
PCT/US1997/005661
Publication Date:
September 17, 1998
Filing Date:
April 04, 1997
Export Citation:
Assignee:
MOTOROLA INC (US)
ACKLEY RICHARD (US)
SHIEH CHAN-LONG (US)
HARVEY THOMAS B III (US)
ACKLEY RICHARD (US)
SHIEH CHAN-LONG (US)
HARVEY THOMAS B III (US)
International Classes:
B01J19/00; C08F2/00; C40B40/06; C40B60/14; C40B70/00; G01N35/10; (IPC1-7): G01N/
Foreign References:
| US5510270A | 1996-04-23 | |||
| US5527681A | 1996-06-18 | |||
| US5368823A | 1994-11-29 | |||
| US5384261A | 1995-01-24 |
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