Title:
METHOD FOR TESTING FOR PSYCHIATRIC DISORDER, TEST KIT FOR PSYCHIATRIC DISORDER, AND METHOD FOR EVALUATING THERAPEUTIC AGENT AND/OR PREVENTION AGENT FOR PSYCHIATRIC DISORDER
Document Type and Number:
WIPO Patent Application WO/2012/017867
Kind Code:
A1
Abstract:
Provided are: a method for testing for a psychiatric disorder by means of an objective determination standard based on a biological indicator through a technique that has a single gene as a subject; an test kit for a psychiatric disorder; and a method for evaluating a therapeutic agent and/or prevention agent for a psychiatric disorder. This method for testing for a psychiatric disorder includes: a detection step for detecting the methylation state at a CpG island upstream from an exon I of the BDNF gene in a sample collected from a subject; and an testing step for comparing the methylation state of the sample and the methylation state of the CpG island upstream from the exon I of the BDNF gene in a sample collected from an individual with the psychiatric disorder and an individual without the psychiatric disorder, thus testing whether or not the subject has the psychiatric disorder. Preferably, the psychiatric disorder is depression and/or schizophrenia.
Inventors:
MORINOBU SHIGERU (JP)
FUCHIKAMI MANABU (JP)
FUCHIKAMI MANABU (JP)
Application Number:
PCT/JP2011/067004
Publication Date:
February 09, 2012
Filing Date:
July 26, 2011
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
MORINOBU SHIGERU (JP)
FUCHIKAMI MANABU (JP)
MORINOBU SHIGERU (JP)
FUCHIKAMI MANABU (JP)
International Classes:
C12Q1/68; C12N15/09
Foreign References:
| JP2010063413A | 2010-03-25 | |||
| JP2009254357A | 2009-11-05 |
Other References:
MORINOBU SHIGERU: "Epigenetic regulation of the BDNF gene and the pathophysiology of depression, The Japanese Society of Clinical Neuropsychopharmacology", THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY GODO NENKAI PROGRAM SHOROKUSHU, vol. 19-39, 2009, pages 104
NOBUSHIGE MORI: "Nanjisei Utsubyo no Chiryo Hannosei Yosoku to Kyakkanteki Shindanho ni Kansuru Seibutsugakuteki Kenkyu", NANJISEI UTSUBYO NO CHIRYO HANNOSEI YOSOKU TO KYAKKANTEKI SHINDANHO NI KANSURU SEIBUTSU SHINRI SHAKAITEKI TOGO KENKYU HEISEI 18 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2007, pages 21 - 24
LUBIN F.D. ET AL.: "Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory", THE JOURNAL OF NEUROSCIENCE, vol. 28, 2008, pages 10576 - 10586
ERI ARAI ET AL.: "Kangan deno DNA Methylation Ijo", MOLECULAR GASTROINTESTINAL MEDICINE, vol. 5, 2008, pages 370 - 375
MILL J. ET AL.: "Epigenomic profiling reveals DNA-methylation changes associated with major psychosis.", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 82, 2008, pages 696 - 711
KELLER S. ET AL.: "Increased BDNF Promoter Methylation in the wernicke area of suicide subjects", ARCHIVES OF GENERAL PSYCHIATRY, vol. 67, March 2010 (2010-03-01), pages 258 - 267, XP002686166, DOI: doi:10.1001/archgenpsychiatry.2010.9
TADAFUMI KATO ET AL.: "Epigenetics of mental disorders", CELL TECHNOLOGY, vol. 28, 2009, pages 567 - 571
NOBUSHIGE MORI: "Nanjisei Utsubyo no Chiryo Hannosei Yosoku to Kyakkanteki Shindanho ni Kansuru Seibutsugakuteki Kenkyu", NANJISEI UTSUBYO NO CHIRYO HANNOSEI YOSOKU TO KYAKKANTEKI SHINDANHO NI KANSURU SEIBUTSU SHINRI SHAKAITEKI TOGO KENKYU HEISEI 18 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2007, pages 21 - 24
LUBIN F.D. ET AL.: "Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory", THE JOURNAL OF NEUROSCIENCE, vol. 28, 2008, pages 10576 - 10586
ERI ARAI ET AL.: "Kangan deno DNA Methylation Ijo", MOLECULAR GASTROINTESTINAL MEDICINE, vol. 5, 2008, pages 370 - 375
MILL J. ET AL.: "Epigenomic profiling reveals DNA-methylation changes associated with major psychosis.", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 82, 2008, pages 696 - 711
KELLER S. ET AL.: "Increased BDNF Promoter Methylation in the wernicke area of suicide subjects", ARCHIVES OF GENERAL PSYCHIATRY, vol. 67, March 2010 (2010-03-01), pages 258 - 267, XP002686166, DOI: doi:10.1001/archgenpsychiatry.2010.9
TADAFUMI KATO ET AL.: "Epigenetics of mental disorders", CELL TECHNOLOGY, vol. 28, 2009, pages 567 - 571
Attorney, Agent or Firm:
KIMURA MITSURU (JP)
Mitsuru Kimura (JP)
Mitsuru Kimura (JP)
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