Title:
METHOD OF TESTING TRANSFUSION COMPATIBILITY IN CANINE BLOOD, AND KIT, MONOCLONAL ANTIBODIES, AND HYBRIDOMA CELL LINES FOR SAME
Document Type and Number:
WIPO Patent Application WO/2019/194360
Kind Code:
A1
Abstract:
The present invention relates to a method of testing transfusion compatibility in canine blood, and a kit, monoclonal antibodies, and hybridoma cell lines for same. More specifically, to verify whether a canine donor blood would cause an immune response in a patient dog, the present invention carries out an antigen-antibody reaction on a canine donor blood sample and a canine patient blood sample by using antibodies, wherein as the antibodies, monoclonal antibodies produced by hybridoma cells of the accession number KCTC 13495BP and monoclonal antibodies produced by the hybridoma cells of the accession number KCTC 13496BP are each brought in contact with each sample before detecting antigen-antibody bonds therefrom. Independent of the DEA blood-grouping system, which is the conventional representative method for testing transfusion compatibility in canine blood, as well as the Dal and Shigeta systems, the method of the present invention makes use of antigens in canine blood, thereby effectively addressing the shortcoming of existing methods for testing transfusion compatibility in canine blood. In particular, the monoclonal antibodies of the present invention each have high specificity to the antigen, and thus can enable extremely accurate and easy assessment.
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Inventors:
KIM HEE YOUNG (KR)
LEE JAE HO (KR)
LEE JANG CHOON (KR)
LEE JAE HO (KR)
LEE JANG CHOON (KR)
Application Number:
PCT/KR2018/007224
Publication Date:
October 10, 2019
Filing Date:
June 26, 2018
Export Citation:
Assignee:
KIM HEE YOUNG (KR)
LEE JAE HO (KR)
LEE JAE HO (KR)
International Classes:
G01N33/577; C07K16/28; C12N5/16; G01N33/564; G01N33/80
Foreign References:
| KR20080089870A | 2008-10-08 | |||
| JPH0989890A | 1997-04-04 |
Other References:
EULER, C.C.: "Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America", J. VET. INTERN. MED., vol. 30, 2016, pages 1642 - 1647, XP055644886
SPADA, E.: "Dog erythrocyte antigens (DEA) 1, 4, 7 and suspected naturally occurring anti-DEA 7 antibodies in Italian Corso dogs", THE VETERINARY JOURNAL, vol. 222, 2017, pages 17 - 21, XP029975711
POLAK, K.: "Dog erythrocyte antigen 1: mode of inheritance and initial characterization", VETERINARY CLINICAL PATHOLOGY, vol. 44, no. 3, 2015, pages 369 - 379, XP055644887
LEE, J. H.: "Kai 1 and Kai 2: Characterization of these dog erythrocyte antigens by monoclonal antibodies", PLOS ONE, vol. 12, no. 6, 29 June 2017 (2017-06-29), pages e0179932, XP055644888
SPADA, E.: "Dog erythrocyte antigens (DEA) 1, 4, 7 and suspected naturally occurring anti-DEA 7 antibodies in Italian Corso dogs", THE VETERINARY JOURNAL, vol. 222, 2017, pages 17 - 21, XP029975711
POLAK, K.: "Dog erythrocyte antigen 1: mode of inheritance and initial characterization", VETERINARY CLINICAL PATHOLOGY, vol. 44, no. 3, 2015, pages 369 - 379, XP055644887
LEE, J. H.: "Kai 1 and Kai 2: Characterization of these dog erythrocyte antigens by monoclonal antibodies", PLOS ONE, vol. 12, no. 6, 29 June 2017 (2017-06-29), pages e0179932, XP055644888
Attorney, Agent or Firm:
HYUNMOON PATENT&LAWFIRM (KR)
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