Title:
METHOD TO ALTER CHINESE HAMSTER OVARY CELL LINE STABILITY
Document Type and Number:
WIPO Patent Application WO/2019/195274
Kind Code:
A3
Abstract:
The present invention provides a recombinant eukaryotic cell expressing one or more heterologous double strand break (DSB) repair proteins in an amount effective for enhancing DSB repair in the cell. The recombinant eukaryotic cell may express a recombinant product of interest. Also provided are methods for enhancing double strand break (DSB) repair in eukaryotic cells, establishing host cells for production of a recombinant product of interest, producing a recombinant product of interest, improving production of a recombinant product of interest by eukaryotic cells, and/or investigating suitability of eukaryotic cells as host cells for producing a recombinant product of interest.
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Inventors:
LEE KELVIN (US)
ZHANG XIAOLIN (US)
ZHANG XIAOLIN (US)
Application Number:
PCT/US2019/025364
Publication Date:
November 07, 2019
Filing Date:
April 02, 2019
Export Citation:
Assignee:
UNIV DELAWARE (US)
International Classes:
C12N15/85; C12N5/07; C12N15/86
Foreign References:
US20150252385A1 | 2015-09-10 |
Other References:
DATABASE UniProtKB [online] 16 November 2011 (2011-11-16), "ATP-dependent DNA helicase 2 subunit 1", XP055650489, Database accession no. G3IJJ1_CRIGR
Attorney, Agent or Firm:
ZHONG, Ling (US)
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