Title:
METHOD OF TRANSFERRING GENE INTO T CELLS
Document Type and Number:
WIPO Patent Application WO/2004/038029
Kind Code:
A1
Abstract:
It is intended to provide a method of transferring a gene into T cells which comprises the step of contacting a paramyxovirus vector with activated T cells. It is also intended to provide a method of producing T cells having a foreign gene transferred thereinto which comprises the step of contacting a paramyxovirus vector with activated T cells. Moreover, it is intended to provide T cells having a foreign gene transferred thereinto which are produced by the above method. Thus, a gene can be efficiently delivered specifically into activated T cells, which is expected as applicable to immunological modification strategies through T cell-directed gene delivery.
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Inventors:
OKANO SHINJI (JP)
YONEMITSU YOSHIKAZU (JP)
SUEISHI KATSUO (JP)
HASEGAWA MAMORU (JP)
YONEMITSU YOSHIKAZU (JP)
SUEISHI KATSUO (JP)
HASEGAWA MAMORU (JP)
Application Number:
PCT/JP2003/013476
Publication Date:
May 06, 2004
Filing Date:
October 22, 2003
Export Citation:
Assignee:
DNAVEC RESEARCH INC (JP)
OKANO SHINJI (JP)
YONEMITSU YOSHIKAZU (JP)
SUEISHI KATSUO (JP)
HASEGAWA MAMORU (JP)
OKANO SHINJI (JP)
YONEMITSU YOSHIKAZU (JP)
SUEISHI KATSUO (JP)
HASEGAWA MAMORU (JP)
International Classes:
C12N7/01; C12N15/86; (IPC1-7): C12N15/86; C12N5/10; C12N7/01
Other References:
SAKAI Y: "Accomodation of foreign genes into the sendai virus genome: sizes of inserted genes and viral replication.", FEBS LETTERS, vol. 456, 1999, pages 221 - 226, XP000887286
OKANO S. ET AL: "Recombinant Sendai virus vectors for activated T Lymphocytes", GENE THERAPY, vol. 10, no. 16, 2003, pages 1381 - 1391, XP002973825
IKEDA A. ET AL: "Recombinant Sendai virus-mediated gene transfer into adult rat retinal tissue:Efficient gene transfer by brief exposure.", EXPERIMENTAL EYE RESEARCH, vol. 75, no. 1, July 2002 (2002-07-01), XP002973826
SHIOTANI A. ET AL: "Skeletal muscle regeneration after insulin-like growth factor I gene transferby recombinant Sendai virus vector.", GENE THERAPY, vol. 8, no. 14, 2001, pages 1043 - 1050, XP008007613
YONEMITSU Y. ET AL: "Efficient gene transfer to airway epithelium using recombinant Sendai virus", NATURE BIOTECHNOLOGY, vol. 18, no. 9, 2000, pages 970 - 973, XP002165781
See also references of EP 1561819A4
OKANO S. ET AL: "Recombinant Sendai virus vectors for activated T Lymphocytes", GENE THERAPY, vol. 10, no. 16, 2003, pages 1381 - 1391, XP002973825
IKEDA A. ET AL: "Recombinant Sendai virus-mediated gene transfer into adult rat retinal tissue:Efficient gene transfer by brief exposure.", EXPERIMENTAL EYE RESEARCH, vol. 75, no. 1, July 2002 (2002-07-01), XP002973826
SHIOTANI A. ET AL: "Skeletal muscle regeneration after insulin-like growth factor I gene transferby recombinant Sendai virus vector.", GENE THERAPY, vol. 8, no. 14, 2001, pages 1043 - 1050, XP008007613
YONEMITSU Y. ET AL: "Efficient gene transfer to airway epithelium using recombinant Sendai virus", NATURE BIOTECHNOLOGY, vol. 18, no. 9, 2000, pages 970 - 973, XP002165781
See also references of EP 1561819A4
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki, JP)
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