Title:
METHOD FOR TREATING ANEMIA USING LONG-ACTING EPO PREPARATION
Document Type and Number:
WIPO Patent Application WO/2016/111575
Kind Code:
A1
Abstract:
The present invention relates to a method for treating anemia using a long-acting EPO preparation and, more specifically, to a method for treating an anemia patient through verification of the safe and long-acting optimum effective dosage and usage when a fusion polypeptide containing EPO and immunoglobulin hybrid Fc is administered to the anemia patient. The administration of the fusion polypeptide leads to excellent long-lasting power compared with existing EPO products, and can be effectively used in the treatment of the anemia patient through the dosage and usage suitable to minimize side effects of the cardiovascular system, which may be caused by a rapid elevation reaction of hemoglobin as an anemia treatment effect.
Inventors:
YANG SANG-IN (KR)
WOO JUNG-WON (KR)
YANG SE HWAN (KR)
SUNG YOUNG CHUL (KR)
PARK DOO HONG (KR)
KIM MIN WOO (KR)
WOO JUNG-WON (KR)
YANG SE HWAN (KR)
SUNG YOUNG CHUL (KR)
PARK DOO HONG (KR)
KIM MIN WOO (KR)
Application Number:
PCT/KR2016/000175
Publication Date:
July 14, 2016
Filing Date:
January 08, 2016
Export Citation:
Assignee:
GENEXINE INC (KR)
GREEN CROSS CORP (KR)
GREEN CROSS CORP (KR)
International Classes:
A61K38/18; A61K38/16; A61P7/06; C07K19/00
Foreign References:
| JP2012107042A | 2012-06-07 | |||
| KR101235124B1 | 2013-03-07 | |||
| KR20090122430A | 2009-11-30 |
Other References:
YANG ET AL.: "A Long-Acting Erythropoietin fused with Noncytolytie Human Fc for the Treatment of Anemia", ARCHIVES OF PHARMACAL RESEARCH, vol. 35, no. 5, 2012, pages 757 - 759, XP035063549, DOI: doi:10.1007/s12272-012-0500-5
SHI ET AL.: "Pharmacokinetics and Pharmacodynamics of Recombinant Human EPO -Fc Fusion Protein in Vivo", PLOS ONE, vol. 8, no. 8, 2013, pages 1 - 7, XP055466525
DATABASE NCBI, Genbank [O] 29 May 2009 (2009-05-29), Database accession no. ACJ06770.1
See also references of EP 3243525A4
SHI ET AL.: "Pharmacokinetics and Pharmacodynamics of Recombinant Human EPO -Fc Fusion Protein in Vivo", PLOS ONE, vol. 8, no. 8, 2013, pages 1 - 7, XP055466525
DATABASE NCBI, Genbank [O] 29 May 2009 (2009-05-29), Database accession no. ACJ06770.1
See also references of EP 3243525A4
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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