Title:
A METHOD OF TREATING CANCER OR A BLOOD DISORDER
Document Type and Number:
WIPO Patent Application WO/2023/287797
Kind Code:
A3
Abstract:
This disclosure provides a method of treating cancer or a blood disorder disease in a patient, the method comprising administering a therapeutically effective amount of a combination of compounds comprising (1) a hypomethylating agent (HMA) and (2) an XP01 inhibitor to a patient. The XP01 inhibitor can be Valtrate or Caffeic acid phenyl ester (CAPE) or salt, hydrate or derivative thereof. Cancers that may be treated with this method include acute myeloid leukemia (AML) particularly leukemias in which a MLL mutation is present or one or both of an NPM1 mutation and an FLT3 mutation is present.
Inventors:
EBRAHEM QUTEBA (US)
Application Number:
PCT/US2022/036834
Publication Date:
February 23, 2023
Filing Date:
July 12, 2022
Export Citation:
Assignee:
EBRAHEM QUTEBA (US)
International Classes:
A61K31/53; A61K36/84; A61P35/02; C07H19/12
Domestic Patent References:
| WO2020232439A1 | 2020-11-19 | |||
| WO2020146440A1 | 2020-07-16 |
Foreign References:
| CA3130244A1 | 2020-08-27 | |||
| US9895391B2 | 2018-02-20 |
Attorney, Agent or Firm:
MAXWELL, Leslie-Anne (US)
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