Title:
METHOD FOR TREATING CANCERS
Document Type and Number:
WIPO Patent Application WO/2021/078126
Kind Code:
A1
Abstract:
Provided herein are methods and formulations for reducing viability of a cancer or enhancing susceptibility of a cancer to an anti-cancer agent. The method includes administering to the subject an effective amount of an anti-parasitic agent and an autophagy inhibitor to the subject. Additionally or optionally, the method further includes administering to the subject the anti-cancer agent. Also provided herein are formulations for the treatment of cancers, particularly cancers that are unresponsive to anti-cancer agents. The formulation includes at least two agents selected from the group consisting of an anti-parasitic agent, an autophagy inhibitor and an HDAC inhibitor; and a pharmaceutically acceptable excipient.
Inventors:
HSU HUNG-KUN (CN)
Application Number:
PCT/CN2020/122269
Publication Date:
April 29, 2021
Filing Date:
October 20, 2020
Export Citation:
Assignee:
ACURA NANOMEDICINE CORP (CN)
International Classes:
A61K31/7048; A61K31/352; A61K31/404; A61K31/4706; A61K31/517; A61P35/00
Foreign References:
| CN104164471A | 2014-11-26 |
Other References:
SUNG SO JUNG, KIM HYUN-KYUNG, HONG YONG-KIL, JOE YOUNG AE: "Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells", BIOMOLECULES & THERAPEUTICS, vol. 27, no. 1, 1 January 2019 (2019-01-01), pages 117 - 125, XP055805773, ISSN: 1976-9148, DOI: 10.4062/biomolther.2018.222
See also references of EP 4048284A4
See also references of EP 4048284A4
Attorney, Agent or Firm:
CHINA ZHENGHE INTELLECTUAL PROPERTY AGENCY (CN)
Download PDF: