Title:
METHOD FOR TREATING DISEASES ASSOCIATED WITH MODIFICATIONS OF QUALITATIVE AND/ QUANTITATIVE COMPOSITION OF BLOOD EXTRACELLULAR DNA (VARIANTS)
Document Type and Number:
WIPO Patent Application WO/2005/004904
Kind Code:
A1
Abstract:
The invention relates to medicine and veterinary science. The inventive method for treating diseases associated with modifications of the qualitative and/or quantitative composition of blood extracellular DNA, namely oncological diseases, infection diseases provoked by bacteria, fungi and protozoa, atherosclerosis, pancreatic diabetes, allergic diseases associated with delayed response hypersensitivity and diseases due to somatic cell gene mutations consists in injecting a blood extracellular DNA binding agent in a systemic blood circulation. In a second variant, an agent modifying the chemical composition and/or conformation and/or polymery of the blood extracellular DNA without destruction thereof is injected into a systemic blood circulation. In a third variant, an agent stimulating the synthesis and/or the activity of endogenic biopolymers which bind or destroy or modify the chemical composition and/or conformation and/or polymery of the blood extracellular DNA without destruction thereof is injected into a systemic blood circulation.
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Inventors:
GENKIN DMITRY DMITRIEVICH (RU)
TETS VIKTOR VENIAMINOVICH (RU)
TETS GEORGY VIKTOROVICH (RU)
TETS VIKTOR VENIAMINOVICH (RU)
TETS GEORGY VIKTOROVICH (RU)
Application Number:
PCT/RU2004/000262
Publication Date:
January 20, 2005
Filing Date:
July 01, 2004
Export Citation:
Assignee:
GENKIN DMITRY DMITRIEVICH (RU)
TETS VIKTOR VENIAMINOVICH (RU)
TETS GEORGY VIKTOROVICH (RU)
TETS VIKTOR VENIAMINOVICH (RU)
TETS GEORGY VIKTOROVICH (RU)
International Classes:
A61K38/47; A61K38/43; A61K38/46; A61K38/50; A61K39/395; A61P3/10; A61P9/10; A61P31/00; A61P33/00; A61P35/00; A61P37/00; C07K16/44; (IPC1-7): A61K38/43; A61K39/395; A61P3/10; A61P9/10; A61P31/00; A61P33/00; A61P35/00; A61P37/00
Foreign References:
| RU2207876C1 | 2003-07-10 | |||
| US5656589A | 1997-08-12 |
Other References:
MELNIKOV D.JU. ET AL.: "Voprosy onkologicheskoi pomoschi na etape reformirovaniya zdravookhraneniya", EKATRIBURG, 1996, pages 159 - 161
RAZ E. ET AL.: "Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney", J. IMMUNOL., vol. 142, no. 9, 1 May 1989 (1989-05-01), pages 3076 - 3082
GORRINI C. ET AL.: "Effect of appoptogenic stimuli on colon carcinoma cell lines with a different c-myc expression level", INT. J. MOL. MED., vol. 11, no. 6, June 2003 (2003-06-01)
SIMPSON G. ET AL.: "Succesful treatment of empyema thoracis with human recombinant deoxyribonuclease", THORAX, vol. 58, no. 4, April 2003 (2003-04-01)
RAZ E. ET AL.: "Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney", J. IMMUNOL., vol. 142, no. 9, 1 May 1989 (1989-05-01), pages 3076 - 3082
GORRINI C. ET AL.: "Effect of appoptogenic stimuli on colon carcinoma cell lines with a different c-myc expression level", INT. J. MOL. MED., vol. 11, no. 6, June 2003 (2003-06-01)
SIMPSON G. ET AL.: "Succesful treatment of empyema thoracis with human recombinant deoxyribonuclease", THORAX, vol. 58, no. 4, April 2003 (2003-04-01)
Attorney, Agent or Firm:
Sandigursky, Oleg Lvovich (St. Petersburg, RU)
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