Title:
METHOD OF TREATING HCV INFECTION WITH A SMALL MOLECULE CHK2 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2013/063462
Kind Code:
A3
Abstract:
A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: G1 is a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted.
Inventors:
SELF CHRISTOPHER (US)
ZHANG GUANGTAO (US)
POMMIER YVES (US)
SHOEMAKER ROBERT H (US)
CURRENS MICHAEL (US)
CARDELLINA JOHN (US)
JOBSON ANDREW (GB)
LOUNTOS GEORGE (US)
SCUDIERO DOMINIC A (US)
ZHANG GUANGTAO (US)
POMMIER YVES (US)
SHOEMAKER ROBERT H (US)
CURRENS MICHAEL (US)
CARDELLINA JOHN (US)
JOBSON ANDREW (GB)
LOUNTOS GEORGE (US)
SCUDIERO DOMINIC A (US)
Application Number:
PCT/US2012/062212
Publication Date:
June 27, 2013
Filing Date:
October 26, 2012
Export Citation:
Assignee:
US HEALTH (US)
PROVID PHARMACEUTICALS INC (US)
SELF CHRISTOPHER (US)
ZHANG GUANGTAO (US)
POMMIER YVES (US)
SHOEMAKER ROBERT H (US)
CURRENS MICHAEL (US)
CARDELLINA JOHN (US)
JOBSON ANDREW (GB)
LOUNTOS GEORGE (US)
SCUDIERO DOMINIC A (US)
WAUGH DAVID (US)
PROVID PHARMACEUTICALS INC (US)
SELF CHRISTOPHER (US)
ZHANG GUANGTAO (US)
POMMIER YVES (US)
SHOEMAKER ROBERT H (US)
CURRENS MICHAEL (US)
CARDELLINA JOHN (US)
JOBSON ANDREW (GB)
LOUNTOS GEORGE (US)
SCUDIERO DOMINIC A (US)
WAUGH DAVID (US)
International Classes:
A61K31/404; A61K31/4178; A61K31/454; A61K31/4709; A61P31/14; C07D209/04
Domestic Patent References:
| WO2008156573A1 | 2008-12-24 |
Foreign References:
| US20090170890A1 | 2009-07-02 | |||
| DE102005025906A1 | 2006-12-07 |
Other References:
ARIUMI YASUO ET AL: "The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.", JOURNAL OF VIROLOGY OCT 2008, vol. 82, no. 19, October 2008 (2008-10-01), pages 9639 - 9646, XP002690329, ISSN: 1098-5514
LOUNTOS GEORGE T ET AL: "X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket.", FEBS LETTERS 20 OCT 2011, vol. 585, no. 20, 20 October 2011 (2011-10-20), pages 3245 - 3249, XP028314412, ISSN: 1873-3468
GEORGE T LOUNTOS ET AL: "Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy", JOURNAL OF STRUCTURAL BIOLOGY, ACADEMIC PRESS, UNITED STATES, vol. 176, no. 3, 19 September 2011 (2011-09-19), pages 292 - 301, XP028104277, ISSN: 1047-8477, [retrieved on 20110922], DOI: 10.1016/J.JSB.2011.09.008
LOUNTOS GEORGE T ET AL: "X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket.", FEBS LETTERS 20 OCT 2011, vol. 585, no. 20, 20 October 2011 (2011-10-20), pages 3245 - 3249, XP028314412, ISSN: 1873-3468
GEORGE T LOUNTOS ET AL: "Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy", JOURNAL OF STRUCTURAL BIOLOGY, ACADEMIC PRESS, UNITED STATES, vol. 176, no. 3, 19 September 2011 (2011-09-19), pages 292 - 301, XP028104277, ISSN: 1047-8477, [retrieved on 20110922], DOI: 10.1016/J.JSB.2011.09.008
Attorney, Agent or Firm:
REIMER, Leah M. (20 Church Street22nd Floo, Hartford Connecticut, US)
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