Title:
A METHOD OF TREATING HIV INFECTION IN ATAZANAVIR RESISTANT PATIENTS USING A COMBINATION OF ATAZANAVIR AND ANOTHER PROTEASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO2005058248
Kind Code:
A3
Abstract:
A method of treating HIV infection in a human patient wherein the infecting HIV strain has become resistant to atazanavir, the method comprising administration of a therapeutically effective amount of a combination of atazanavir or a pharmaceutically acceptable salt thereof, and at least one other HIV protease inhibitor. A method for enhancing the effectiveness of a second HIV protease inhibitor in treating HIV infection in a human patient whose HIV strain has become resistant to atazanavir or a pharmaceutically acceptable salt thereof, comprising administering to said human patient an amount of atazanavir or a pharmaceutically acceptable salt thereof effective in maintaining the resistant strain, in combination with the second HIV protease inhibitor. The resistance to atazanavir in the human is manifested by the existence of the signature mutation consisting of I50L mutation in the HIV protease.
Inventors:
COLONNO RICHARD J (US)
FRIBORG JR JACQUES (US)
ROSE RONALD E (US)
FRIBORG JR JACQUES (US)
ROSE RONALD E (US)
Application Number:
PCT/US2004/041968
Publication Date:
October 27, 2005
Filing Date:
December 14, 2004
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
COLONNO RICHARD J (US)
FRIBORG JR JACQUES (US)
ROSE RONALD E (US)
COLONNO RICHARD J (US)
FRIBORG JR JACQUES (US)
ROSE RONALD E (US)
International Classes:
A61K31/44; A61K31/551; A61K31/7056; A61K; (IPC1-7): A61K31/44
Foreign References:
| US6110946A | 2000-08-29 | |||
| US6100277A | 2000-08-08 |
Other References:
See also references of EP 1696918A4
Download PDF: