Title:
METHOD FOR TREATING INFECTIOUS DISEASES BY TARGETING NK CELL IMMUNE CHECKPOINT
Document Type and Number:
WIPO Patent Application WO/2020/192572
Kind Code:
A1
Abstract:
Provided is a method of preventing or treating an infectious disease in a subject, comprising the step of administering to the subject an antagonist or expression inhibitor for a natural killer (NK) cell immune checkpoint molecule. Further provided is the use of an antagonist or expression inhibitor for an NK cell immune checkpoint molecular and pharmaceutical compositions comprising the same in the treatment of infectious diseases.
Inventors:
TANG HONG (CN)
ZHANG CHAO (CN)
CHEN HAIRONG (CN)
ZHANG CHAO (CN)
CHEN HAIRONG (CN)
Application Number:
PCT/CN2020/080365
Publication Date:
October 01, 2020
Filing Date:
March 20, 2020
Export Citation:
Assignee:
INST PASTEUR SHANGHAI CAS (CN)
International Classes:
A61K45/00; A61K39/395; A61P31/14; A61P31/18; A61P31/20
Domestic Patent References:
| WO2006070286A2 | 2006-07-06 | |||
| WO2006072624A2 | 2006-07-13 |
Foreign References:
| CN109384846A | 2019-02-26 | |||
| CN109833480A | 2019-06-04 |
Other References:
GULIDANNA SHAYAN; RAGHVENDRA SRIVASTAVA; JING LI; NICOLE SCHMITT; LAWRENCE P KANE; ROBERT L FERRIS: "High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer.", ONCOIMMUNOLOGY, vol. 6, no. 1, e1261779, 7 December 2016 (2016-12-07), pages 1 - 11, XP055525688, ISSN: 2162-4011, DOI: 10.1080/2162402X.2016.1261779
VERON RAMSURAN, NARANBHAI VIVEK, HOROWITZ AMIR, QI YING, MARTIN MAUREEN P., YUKI YUKO, GAO XIAOJIANG, WALKER-SPERLING VICTORIA, DE: "Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.", SCIENCE, vol. 359, no. 6371, 5 January 2018 (2018-01-05), pages 86 - 90, XP055738077, ISSN: 0036-8075, DOI: 10.1126/science.aam8825
FENGLEI LI; HAIRONG WEI; HAIMING WEI; YUFENG GAO; LONG XU; WENWEI YIN; RUI SUN; ZHIGANG TIAN: "Blocking the Natural Killer Cell Inhibitory Receptor NKG2A Increases Activity of Human Natural Killer Cells and Clears Hepatitis B Virus Infection in Mice.", GASTROENTEROLOGY, vol. 144, no. 2, 28 February 2013 (2013-02-28), pages 392 - 401, XP055724069, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2012.10.039
ZHANG QING; BI JIACHENG; ZHENG XIAODONG; CHEN YONGYAN; WANG HUA; WU WENYONG; WANG ZHENGGUANG; WU QIANG; PENG HUI; WEI HAIMING; SUN: "Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity.", NATURE IMMUNOLOGY, vol. 19, no. 7, 18 June 2018 (2018-06-18), pages 723 - 732, XP036533618, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0132-0
ASMA BELDI-FERCHIOU , SOPHIE CAILLAT-ZUCMAN: "Control of NK Cell Activation by Immune Checkpoint Molecules", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, no. 10, 2129, 12 October 2017 (2017-10-12), pages 1 - 15, XP055738082, DOI: 10.3390/ijms18102129
See also references of EP 3927377A4
VERON RAMSURAN, NARANBHAI VIVEK, HOROWITZ AMIR, QI YING, MARTIN MAUREEN P., YUKI YUKO, GAO XIAOJIANG, WALKER-SPERLING VICTORIA, DE: "Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.", SCIENCE, vol. 359, no. 6371, 5 January 2018 (2018-01-05), pages 86 - 90, XP055738077, ISSN: 0036-8075, DOI: 10.1126/science.aam8825
FENGLEI LI; HAIRONG WEI; HAIMING WEI; YUFENG GAO; LONG XU; WENWEI YIN; RUI SUN; ZHIGANG TIAN: "Blocking the Natural Killer Cell Inhibitory Receptor NKG2A Increases Activity of Human Natural Killer Cells and Clears Hepatitis B Virus Infection in Mice.", GASTROENTEROLOGY, vol. 144, no. 2, 28 February 2013 (2013-02-28), pages 392 - 401, XP055724069, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2012.10.039
ZHANG QING; BI JIACHENG; ZHENG XIAODONG; CHEN YONGYAN; WANG HUA; WU WENYONG; WANG ZHENGGUANG; WU QIANG; PENG HUI; WEI HAIMING; SUN: "Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity.", NATURE IMMUNOLOGY, vol. 19, no. 7, 18 June 2018 (2018-06-18), pages 723 - 732, XP036533618, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0132-0
ASMA BELDI-FERCHIOU , SOPHIE CAILLAT-ZUCMAN: "Control of NK Cell Activation by Immune Checkpoint Molecules", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, no. 10, 2129, 12 October 2017 (2017-10-12), pages 1 - 15, XP055738082, DOI: 10.3390/ijms18102129
See also references of EP 3927377A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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