Title:
METHOD FOR TREATING PREGANCY-INDUCED HYPERTENSION NEPHROSIS
Document Type and Number:
WIPO Patent Application WO/2020/166557
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a method for treating pregnancy-induced hypertension nephrosis, the method being characterized by administering antithrombin; and a novel composition for treating pregnancy-induced hypertension nephrosis, the composition comprising antithrombin. The present invention relates to: a method for treating pregnancy-induced hypertension nephrosis, the method being characterized by administering antithrombin to a pregnancy-induced hypertension nephrosis patient with 100% or lower blood antithrombin activity; and a composition for treating pregnancy-induced hypertension nephrosis, the composition comprising antithrombin and characterized in that antithrombin is administered to a pregnancy-induced hypertension nephrosis patient with 100% or lower blood antithrombin activity.
Inventors:
NAKAMURA YOSHIHIDE (JP)
MURAYAMA TAKASHI (JP)
TAKAGI KENICHI (JP)
SHIMAZAKI RYUTARO (JP)
ENDO YUICHI (JP)
KANDA HIRONORI (JP)
MOTOYAMA KAYOKO (JP)
KATO MASAYA (JP)
ORIHARA SHUNICHIRO (JP)
TANAKA TOMOKO (JP)
MURAYAMA TAKASHI (JP)
TAKAGI KENICHI (JP)
SHIMAZAKI RYUTARO (JP)
ENDO YUICHI (JP)
KANDA HIRONORI (JP)
MOTOYAMA KAYOKO (JP)
KATO MASAYA (JP)
ORIHARA SHUNICHIRO (JP)
TANAKA TOMOKO (JP)
Application Number:
PCT/JP2020/005130
Publication Date:
August 20, 2020
Filing Date:
February 10, 2020
Export Citation:
Assignee:
KYOWA KIRIN CO LTD (JP)
International Classes:
A61K38/55; A61P7/02; A61P13/12
Domestic Patent References:
| WO2016159204A1 | 2016-10-06 | |||
| WO2005035563A1 | 2005-04-21 | |||
| WO2008120801A1 | 2008-10-09 |
Foreign References:
| JPH07316072A | 1995-12-05 | |||
| US201962803888P | 2019-02-11 | |||
| US201962820459P | 2019-03-19 |
Other References:
MAKI M. ET AL.: "Antithrombin therapy for severe preeclampsia: results of a double-blind, randomized, placebo-controlled trial.", THROMB HAEMOST., vol. 84, 2000, pages 583 - 90, XP055212802
TOSHIHIKO TERAO: "AT—III concentrate adminstration on obstetrical DIC. [Coagulation inhibitor therapy, antithrombin III therapy - obstetrics and gynecology]", BIOMEDICAL PERSPECTIVES, vol. 8, no. 1, 30 November 1998 (1998-11-30), pages 68 - 78, XP009529416, ISSN: 0918-6514
SUZUKI HIROMICHI: "VI. Pregnancy-induced Hypertension", THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 104, no. 2, 10 February 2015 (2015-02-10), JP, pages 247 - 252, XP009529419, ISSN: 0021-5384, DOI: 10.2169/naika.104.247
PROC. NATL. ACAD. SCI. USA., vol. 80, 1983, pages 1845 - 1848
MARK A. BROWN, HYPERTENSION, vol. 72, 2018, pages 24 - 43
"New Definition and Classification of Hypertensive Disorders of Pregnancy", 2019, JAPAN SOCIETY FOR THE STUDY OF HYPERTENSION IN PREGNANCY
BARTON ET AL., AM J OBSTET GYNECOL., vol. 184, no. 5, 2001, pages 979 - 83
XIONG ET AL., J REPROD MED., vol. 52, no. 5, 2007, pages 402 - 6
CONTRIB. NEPHROL., vol. 25, 1981, pages 108 - 110
SEKI ET AL., ACTA OBSTET GYNECOL SCAND., vol. 93, no. 10, 2014, pages 959 - 64
AHMAD ET AL., VASC CELL, vol. 3, no. 1, 2011, pages 15
WALSHE ET AL., PLOS ONE, vol. 4, no. 4, 2009, pages e5149
LOCKWOOD ET AL., AM J PATHOL., vol. 170, no. 4, 2007, pages 1398 - 1405
TOKUMASU H ET AL., PEDIATR INT., vol. 58, no. 7, 2016, pages 578 - 583
NAKANISHI H ET AL., J PERINATOL., vol. 38, no. 7, 2018, pages 917 - 928
"Practice Guide for Hypertensive Disorders of Pregnancy", 2015, MEDICAL VIEW CO., LTD., pages: 251
SHINNDAN TO SHINNYAKU, vol. 33, no. 1, 1996, pages 67 - 94
THROMB HAEMOST, vol. 84, 2000, pages 583 - 590
"LB02 Supplement to MONTH", AMERICAN JOURNAL OF OBSTETIC, 2017, pages 559
"Notice on Changes to General Designations for Extracorporeal Diagnostic Drugs", PHARMACEUTICAL AND FOOD SAFETY BUREAU NOTICE, vol. 0329, no. 10, 29 March 2011 (2011-03-29)
TOSHIHIKO TERAO: "AT—III concentrate adminstration on obstetrical DIC. [Coagulation inhibitor therapy, antithrombin III therapy - obstetrics and gynecology]", BIOMEDICAL PERSPECTIVES, vol. 8, no. 1, 30 November 1998 (1998-11-30), pages 68 - 78, XP009529416, ISSN: 0918-6514
SUZUKI HIROMICHI: "VI. Pregnancy-induced Hypertension", THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 104, no. 2, 10 February 2015 (2015-02-10), JP, pages 247 - 252, XP009529419, ISSN: 0021-5384, DOI: 10.2169/naika.104.247
PROC. NATL. ACAD. SCI. USA., vol. 80, 1983, pages 1845 - 1848
MARK A. BROWN, HYPERTENSION, vol. 72, 2018, pages 24 - 43
"New Definition and Classification of Hypertensive Disorders of Pregnancy", 2019, JAPAN SOCIETY FOR THE STUDY OF HYPERTENSION IN PREGNANCY
BARTON ET AL., AM J OBSTET GYNECOL., vol. 184, no. 5, 2001, pages 979 - 83
XIONG ET AL., J REPROD MED., vol. 52, no. 5, 2007, pages 402 - 6
CONTRIB. NEPHROL., vol. 25, 1981, pages 108 - 110
SEKI ET AL., ACTA OBSTET GYNECOL SCAND., vol. 93, no. 10, 2014, pages 959 - 64
AHMAD ET AL., VASC CELL, vol. 3, no. 1, 2011, pages 15
WALSHE ET AL., PLOS ONE, vol. 4, no. 4, 2009, pages e5149
LOCKWOOD ET AL., AM J PATHOL., vol. 170, no. 4, 2007, pages 1398 - 1405
TOKUMASU H ET AL., PEDIATR INT., vol. 58, no. 7, 2016, pages 578 - 583
NAKANISHI H ET AL., J PERINATOL., vol. 38, no. 7, 2018, pages 917 - 928
"Practice Guide for Hypertensive Disorders of Pregnancy", 2015, MEDICAL VIEW CO., LTD., pages: 251
SHINNDAN TO SHINNYAKU, vol. 33, no. 1, 1996, pages 67 - 94
THROMB HAEMOST, vol. 84, 2000, pages 583 - 590
"LB02 Supplement to MONTH", AMERICAN JOURNAL OF OBSTETIC, 2017, pages 559
"Notice on Changes to General Designations for Extracorporeal Diagnostic Drugs", PHARMACEUTICAL AND FOOD SAFETY BUREAU NOTICE, vol. 0329, no. 10, 29 March 2011 (2011-03-29)
Attorney, Agent or Firm:
Eikoh Patent Firm, P.C. (JP)
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