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Title:
METHOD FOR TREATING AND/OR PREVENTING NEUROPATHIC PAIN
Document Type and Number:
WIPO Patent Application WO/2019/135407
Kind Code:
A1
Abstract:
The present invention provides: a composition for treating and/or preventing neuropathic pain, the composition comprising a culture supernatant of dental pulp stem cells; a method for treating and/or preventing neuropathic pain, the method comprising a step for administering an effective dose of culture supernatant of dental pulp stem cells to a subject patient; and a method for manufacturing a composition for treating and/or preventing neuropathic pain, the method comprising a step for culturing dental pulp stem cells and a step for recovering culture supernatant.

Inventors:
YAMAMOTO, Akihito (2-24 Shinkura-cho, Tokushima-sh, Tokushima 01, 〒7708501, JP)
TANAKA, Eiji (2-24 Shinkura-cho, Tokushima-sh, Tokushima 01, 〒7708501, JP)
LIU, Yao (2-24 Shinkura-cho, Tokushima-sh, Tokushima 01, 〒7708501, JP)
Application Number:
JP2019/000015
Publication Date:
July 11, 2019
Filing Date:
January 04, 2019
Export Citation:
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Assignee:
TOKUSHIMA UNIVERSITY (2-24, Shinkura-cho Tokushima-sh, Tokushima 01, 〒7708501, JP)
International Classes:
A61K35/12; A61K35/32; A61P25/04; A61P29/00
Domestic Patent References:
WO2014126176A12014-08-21
Other References:
LINDENLAUB, THIES ET AL.: "Effects of neutralizing antibodies to INF-alpha on pain-related behavior and nerve regeneration in mice with chronic constriction injury", BRAIN RESEARCH, vol. 866, no. 1-2, 2000, pages 15 - 22, XP055621294
SCHAFERS, MARIA ET AL.: "Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice", NEUROSCIENCE LETTERS, vol. 310, 2001, pages 113 - 116, XP009072275
BRINI, A. T. ET AL.: "Therapeutic effect of human adipose-derived stem cells and their secretome in experimental diabetic pain", SCIENTIFIC REPORTS, vol. 7, no. 9904, 2017, pages 1 - 15
Attorney, Agent or Firm:
YAMAO, Norihito et al. (AOYAMA & PARTNERS, Umeda Hankyu Bldg. Office Tower 8-1, Kakuda-cho, Kita-ku, Osaka-sh, Osaka 17, 〒5300017, JP)
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