METHOD FOR TREATING SJOGREN'S SYNDROME USING TACI-FC FUSION PROTEIN

Title:

METHOD FOR TREATING SJOGREN'S SYNDROME USING TACI-FC FUSION PROTEIN

Document Type and Number:

WIPO Patent Application WO/2023/051660

Kind Code:

A1

Abstract:

Provided are a drug for treating Sjogren's syndrome using a TACI-Fc fusion protein, and a dosage regimen, a dosing interval and an administration mode thereof. The results show that the provided TACI-Fc fusion protein significantly improves the ESDAI score and the MF-20 score at 24 weeks in a patient with Sjogren's syndrome, and same exhibits good security during treatment.

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Inventors:

FANG JIANMIN (CN)
WANG WENXIANG (CN)

Application Number:

PCT/CN2022/122399

Publication Date:

April 06, 2023

Filing Date:

September 29, 2022

Export Citation:

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Assignee:

REMEGEN CO LTD (CN)

International Classes:

C07K19/00; A61P37/00

Foreign References:

CN101323643A	2008-12-17
CN110522908A	2019-12-03
CN102085368A	2011-06-08
CN101628111A	2010-01-20
CN101854951A	2010-10-06
CN101489573A	2009-07-22
US5969102A	1999-10-19
US6316222B1	2001-11-13
US6500428B1	2002-12-31
US9569245A
US9627206A	2006-12-05
CN101323643A	2008-12-17

Other References:

"A Study of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Primary Sjögren's Syndrom", HISTORY OF CHANGES FOR STUDY: NCT04078386, 13 August 2021 (2021-08-13), XP093054611, Retrieved from the Internet
J.BIOL.CHEM, vol. 243, 1968, pages 3558

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