Title:
METHOD FOR TREATING TUMORS BY MEANS OF COMBINING EXOGENOUS ANTIGEN WITH THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2023/124973
Kind Code:
A1
Abstract:
Disclosed in the present invention is a method for treating tumors by means of combining an exogenous antigen with a therapeutic agent, which belongs to the technical field of gene therapy. Disclosed in present invention is a composition, which contains an exogenous antigen and a therapeutic agent, wherein the therapeutic agent kills a tissue or a cell containing the exogenous antigen by means of taking the exogenous antigen as a target, and does not act on a tissue or a cell free of the exogenous antigen, thereby specifically killing the tissue or the cell, such as a tumor cell. On the basis that the exogenous antigen can be expressed in different types of tumors in different individuals, the method of the present invention is a broad-spectrum anti-tumor method.
Inventors:
ZHOU CHAO (CN)
AN HONG (CN)
ZHOU LING (CN)
DU YONGBIAO (CN)
LIAO PENGYUN (CN)
WANG TAOXI (CN)
YIN HAIBIN MICHAEL (CN)
AN HONG (CN)
ZHOU LING (CN)
DU YONGBIAO (CN)
LIAO PENGYUN (CN)
WANG TAOXI (CN)
YIN HAIBIN MICHAEL (CN)
Application Number:
PCT/CN2022/138691
Publication Date:
July 06, 2023
Filing Date:
December 13, 2022
Export Citation:
Assignee:
GUANGZHOU ANJIE BIOMEDICAL TECH CO LTD (CN)
International Classes:
A61K45/00; A61P35/00; C12N7/01; C12N15/867
Foreign References:
| CN114344472A | 2022-04-15 | |||
| CN110856724A | 2020-03-03 | |||
| US20210077554A1 | 2021-03-18 | |||
| CN110856751A | 2020-03-03 |
Other References:
WING ANNA, FAJARDO CARLOS ALBERTO, POSEY, SHAW CAROLYN, DA TONG, YOUNG REGINA M, ALEMANY RAMON, JUNE CARL H, GUEDAN SONIA: "Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager", CANCER IMMUNOLOGY RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 6, no. 5, 1 May 2018 (2018-05-01), US , pages 605 - 616, XP009517684, ISSN: 2326-6066, DOI: 10.1158/2326-6066.CIR-17-0314
HOFFMANN DENNIS, GRUNWALD THOMAS, KUATE SERAPHIN, WILDNER OLIVER: "Mechanistic analysis and comparison of viral fusogenic membrane proteins for their synergistic effects on chemotherapy", CANCER BIOLOGY & THERAPY, LANDES BIOSCIENCE, US, vol. 6, no. 4, 10 April 2007 (2007-04-10), US , pages 510 - 518, XP093074774, ISSN: 1538-4047, DOI: 10.4161/cbt.6.4.3815
ROSEWELL SHAW AMANDA, PORTER CAROLINE E., YIP TIFFANY, MAH WAY-CHAMP, MCKENNA MARY K., DYSTHE MATTHEW, JUNG YOUNGROCK, PARIHAR ROB: "Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors", COMMUNICATIONS BIOLOGY, vol. 4, no. 1, XP093074777, DOI: 10.1038/s42003-021-01914-8
KIYONORI TANOUE, AMANDA ROSEWELL SHAW, NORIHIRO WATANABE, CAROLINE PORTER, BHAKTI RANA, STEPHEN GOTTSCHALK, MALCOLM BRENNER, MASAT: "Armed Oncolytic Adenovirus–Expressing PD-L1 Mini-Body Enhances Antitumor Effects of Chimeric Antigen Receptor T Cells in Solid Tumors", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 77, no. 8, 15 April 2017 (2017-04-15), US, pages 2040 - 2051, XP055384740, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-16-1577
HOFFMANN DENNIS, GRUNWALD THOMAS, KUATE SERAPHIN, WILDNER OLIVER: "Mechanistic analysis and comparison of viral fusogenic membrane proteins for their synergistic effects on chemotherapy", CANCER BIOLOGY & THERAPY, LANDES BIOSCIENCE, US, vol. 6, no. 4, 10 April 2007 (2007-04-10), US , pages 510 - 518, XP093074774, ISSN: 1538-4047, DOI: 10.4161/cbt.6.4.3815
ROSEWELL SHAW AMANDA, PORTER CAROLINE E., YIP TIFFANY, MAH WAY-CHAMP, MCKENNA MARY K., DYSTHE MATTHEW, JUNG YOUNGROCK, PARIHAR ROB: "Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors", COMMUNICATIONS BIOLOGY, vol. 4, no. 1, XP093074777, DOI: 10.1038/s42003-021-01914-8
KIYONORI TANOUE, AMANDA ROSEWELL SHAW, NORIHIRO WATANABE, CAROLINE PORTER, BHAKTI RANA, STEPHEN GOTTSCHALK, MALCOLM BRENNER, MASAT: "Armed Oncolytic Adenovirus–Expressing PD-L1 Mini-Body Enhances Antitumor Effects of Chimeric Antigen Receptor T Cells in Solid Tumors", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 77, no. 8, 15 April 2017 (2017-04-15), US, pages 2040 - 2051, XP055384740, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-16-1577
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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