Title:
METHOD FOR THE TREATMENT OR DIAGNOSIS OF HUMAN PATHOLOGIES WITH DISSEMINATED OR DIFFICULT TO ACCESS CELLS OR TISSUES
Document Type and Number:
WIPO Patent Application WO1999013054
Kind Code:
A3
Abstract:
Method for the treatment or diagnosis of pathologies either expressed in injured or pathological multiple sites in tissues or in the body or expressed in injured or pathological sites of tissues or cells in sites of the body, which are difficult to access, with said sites or areas in immediate proximity to said sites being the source of the release of chemotactic factors for endogenous macrophages, either spontaneously or upon suitable stimulation, wherein said treatment is carried out by administration to the body of an appropriate amount of exogenous monocyte derived cells, said monocyte derived cells being, in the case of treatment, loaded with corrective agents with respect to the pathologies to be treated, and with said monocyte derived cells having the properties of mobilisation towards the source of the above-said released chemotactic factors and to target the cells present in the vicinity of the said released chemotactic factors, and in the case of diagnosis, loaded with a marker enabling the detection of injured or pathological sites.
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Inventors:
DREYFUS PATRICK A (FR)
PARRISH ELAINE (FR)
GARCIA LUIS (FR)
CHOKRI MOHAMED (FR)
BARTHOLEYNS JACQUES (FR)
PELTEKIAN ELISE (FR)
PARRISH ELAINE (FR)
GARCIA LUIS (FR)
CHOKRI MOHAMED (FR)
BARTHOLEYNS JACQUES (FR)
PELTEKIAN ELISE (FR)
Application Number:
PCT/EP1998/005707
Publication Date:
May 06, 1999
Filing Date:
August 31, 1998
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
IDM IMMUNO DESIGNED MOLECULES (FR)
DREYFUS PATRICK A (FR)
PARRISH ELAINE (FR)
GARCIA LUIS (FR)
CHOKRI MOHAMED (FR)
BARTHOLEYNS JACQUES (FR)
PELTEKIAN ELISE (FR)
IDM IMMUNO DESIGNED MOLECULES (FR)
DREYFUS PATRICK A (FR)
PARRISH ELAINE (FR)
GARCIA LUIS (FR)
CHOKRI MOHAMED (FR)
BARTHOLEYNS JACQUES (FR)
PELTEKIAN ELISE (FR)
International Classes:
C12N15/09; A61K35/14; A61K38/00; A61K48/00; A61P9/10; A61P11/00; A61P19/02; A61P19/08; A61P21/00; A61P25/00; A61P25/02; C12N5/0786; C12N5/10; G01N33/569; G01N33/68; (IPC1-7): C12N5/08
Domestic Patent References:
| WO1995006120A1 | 1995-03-02 | |||
| WO1996022781A1 | 1996-08-01 |
Other References:
PARRISH E P ET AL: "Targeting widespread sites of damage in dystrophic muscle: engrafted macrophages as potential shuttles.", GENE THERAPY, (1996 JAN) 3 (1) 13-20, XP002094551
PARRISH, E. ET AL: "Gene therapy for neuromuscular disorders: macrophages as shuttles for widespread targeting", NEW DEV. NEW APPL. ANIM. CELL TECHNOL., PROC. ESACT MEET., 15TH (1998), MEETING DATE 1997, 531-539. EDITOR(S): MERTEN, OTTO-WILHELM;PERRIN, PIERRE; GRIFFITHS, BRYAN, XP002094552
PARRISH, E. ET AL: "Gene therapy for neuromuscular disorders: macrophages as shuttles for widespread targeting", NEW DEV. NEW APPL. ANIM. CELL TECHNOL., PROC. ESACT MEET., 15TH (1998), MEETING DATE 1997, 531-539. EDITOR(S): MERTEN, OTTO-WILHELM;PERRIN, PIERRE; GRIFFITHS, BRYAN, XP002094552
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