Title:
METHOD OF TREATMENT OF FOLLICULAR LYMPHOMA WITH A BTK INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2017/087947
Kind Code:
A3
Abstract:
Disclosed herein are methods of treating follicular lymphoma in an individual in need thereof wherein the individual has an overexpression of one or more genes selected from CALB2, P2RY11 (PPAN-P2RY11), DNAJC8, TTC19, VCAMl, CSAG3, GP1BA, RPA1, RSC1A1, STS-1 (UBASH3B), ADPRM (C170RF48) and FILIPl, or a normal expression or underexpression of one or more genes selected from CERCAM, POM121C (LOC100131972), PPP1R3D, PLOD2, SDHA (SDHAP3), OSBPL2, HCFC1R1, and DHRS7, which method comprises administering or continuing to administer to the individual a therapeutically effective amount of ibrutinib or a pharmaceutically acceptable salt or solvate thereof.
Inventors:
WANG ZHENGYUANG (US)
CHANG BETTY (US)
CHEUNG LEO (US)
ECKERT KARL (US)
SCHWEIGHOFER KARL (US)
WU SHIQUAN (US)
CHANG BETTY (US)
CHEUNG LEO (US)
ECKERT KARL (US)
SCHWEIGHOFER KARL (US)
WU SHIQUAN (US)
Application Number:
PCT/US2016/063085
Publication Date:
July 06, 2017
Filing Date:
November 21, 2016
Export Citation:
Assignee:
PHARMACYCLICS LLC (US)
WANG ZHENGYUANG (US)
WANG ZHENGYUANG (US)
International Classes:
C12Q1/68; A61K31/519; A61P35/00
Domestic Patent References:
| WO2014168975A1 | 2014-10-16 |
Foreign References:
| US20110059854A1 | 2011-03-10 |
Attorney, Agent or Firm:
RUSSELL, Hathaway, P. et al. (US)
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