Title:
METHOD FOR TREATMENT AND/OR PREVENTION OF OSTEOARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2019/230859
Kind Code:
A1
Abstract:
Provided are a cartilage-regeneration composition containing dental pulp stem cells and/or culture supernatant thereof, and a method for producing the composition, comprising culturing dental pulp stem cells and recovering the dental pulp stem cells and/or culture supernatant thereof. Provided are a composition for treatment and/or prevention of osteoarthritis, containing dental pulp stem cells and/or culture supernatant thereof, and a method for producing the composition, comprising culturing dental pulp stem cells and recovering the dental pulp stem cells and/or culture supernatant thereof.
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Inventors:
YAMAMOTO AKIHITO (JP)
TANAKA EIJI (JP)
OGASAWARA NAOKO (JP)
TANAKA EIJI (JP)
OGASAWARA NAOKO (JP)
Application Number:
PCT/JP2019/021448
Publication Date:
December 05, 2019
Filing Date:
May 30, 2019
Export Citation:
Assignee:
UNIV TOKUSHIMA (JP)
International Classes:
A61K35/32; A61P19/00; A61P19/02
Foreign References:
| CN108042568A | 2018-05-18 | |||
| CN106390099A | 2017-02-15 |
Other References:
MATA, M. ET AL.: "In Vivo Articular Cartilage Regeneration Using Human Dental Pulp Stem Cells Cultured in an Alginate Scaffold: A Preliminary Study", STEM CELLS INT, vol. 2017, 2017, pages 1 - 9, XP055662225, ISSN: 1687-9678
ISHIKAWA, J. ET AL.: "Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis", BONE, vol. 83, 2016, pages 210 - 9, XP029385167, ISSN: 8756-3282, DOI: 10.1016/j.bone.2015.11.012
PLATAS, J. ET AL.: "Conditioned Media from Adipose-Tissue-Derived Mesenchymal Stem Cells Downregulate Degradative Mediators Induced by Interleukin-1beta in Osteoarthritic Chondrocytes", MEDIATORS INFLAMM, vol. 2013, 2013, pages 1 - 10, XP055662227, ISSN: 0962-9351
KHATAB, S. ET AL.: "MESENCHYMAL STEM CELL SECRETOME REDUCES PAIN AND SUBCHONDRAL BONE ALTERATIONS IN A MOUSE OSTEOARTHRITIS MODEL", OSTEOARTHR CARTIL, vol. 26, no. 1, April 2018 (2018-04-01), pages S15 - S16, XP055662232, ISSN: 1063-4584
OGASSAWARA NAOKO ET AL.: "Evaluation of therapeutic effect of serum-free conditioned medium derived from SHED for TMJ-OA", PROGRAM AND PROCEEDINGS OF THE 77TH ANNUAL MEETING OF THE JAPANESE ORTHODONTIC SOCIETY AND KOREAN ASSOCIATION OF ORTHODONTISTS, October 2018 (2018-10-01), pages 245
ISHIKAWA, J. ET AL.: "Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis", BONE, vol. 83, 2016, pages 210 - 9, XP029385167, ISSN: 8756-3282, DOI: 10.1016/j.bone.2015.11.012
PLATAS, J. ET AL.: "Conditioned Media from Adipose-Tissue-Derived Mesenchymal Stem Cells Downregulate Degradative Mediators Induced by Interleukin-1beta in Osteoarthritic Chondrocytes", MEDIATORS INFLAMM, vol. 2013, 2013, pages 1 - 10, XP055662227, ISSN: 0962-9351
KHATAB, S. ET AL.: "MESENCHYMAL STEM CELL SECRETOME REDUCES PAIN AND SUBCHONDRAL BONE ALTERATIONS IN A MOUSE OSTEOARTHRITIS MODEL", OSTEOARTHR CARTIL, vol. 26, no. 1, April 2018 (2018-04-01), pages S15 - S16, XP055662232, ISSN: 1063-4584
OGASSAWARA NAOKO ET AL.: "Evaluation of therapeutic effect of serum-free conditioned medium derived from SHED for TMJ-OA", PROGRAM AND PROCEEDINGS OF THE 77TH ANNUAL MEETING OF THE JAPANESE ORTHODONTIC SOCIETY AND KOREAN ASSOCIATION OF ORTHODONTISTS, October 2018 (2018-10-01), pages 245
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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