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Title:
METHOD OF TREATMENT OF TALC
Document Type and Number:
WIPO Patent Application WO/1995/020542
Kind Code:
A1
Abstract:
The way of talc treatment consists in the mixing-up 74 up to 89 weight % of water, 10 up to 20 weight % of talc and 1 up to 6 weight % of hydrochloric acid and the resulting substance is heated at constant stirring in 0.5 up to 6 hours to the temperature 40 �C up to 60 �C and it is maintained at this temperature during 1 up to 6 hours. Out of the reaction mixture there is afterwards separated the sediment and following the adjustment of its acidity to the pH value 5 up to 8 it is mixed with water and sulphuric acid in the ratio 10 up to 20 volume % of sediment, 74 up to 89 volume % of water and 1 up to 6 volume % of sulphuric acid in dependence with the laboratory temperature, and at constant stirring is the reaction mixture heated during 0.5 hour up to 6 hours to the temperature 75 �C up to 125 �C and it is maintained at this temperature until the time when there is reached a quasi unchangeable value of the iron content in the reaction mixture, and then the sediment is separated, its acidity is adjusted to the pH value 5 up to 8 and subsequently it is dried and sterilized at the temperature 160 �C up to 250 �C during two up to four hours.

Inventors:
KOVANDA IVAN (SK)
POBIS KAROL (SK)
SMIDAK JOZEF (SK)
SMATANA JURAJ (SK)
Application Number:
PCT/SK1995/000001
Publication Date:
August 03, 1995
Filing Date:
January 27, 1995
Export Citation:
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Assignee:
TANO CONTO (SK)
KOVANDA IVAN (SK)
POBIS KAROL (SK)
SMIDAK JOZEF (SK)
SMATANA JURAJ (SK)
International Classes:
A61K9/00; A61K47/02; C01B33/22; C09C1/28; (IPC1-7): C01B33/22
Foreign References:
US2574895A1951-11-13
GB2211493A1989-07-05
Other References:
CHEMICAL ABSTRACTS, vol. 84, no. 8, 23 February 1976, Columbus, Ohio, US; abstract no. 45347u, page 51;
CHEMICAL ABSTRACTS, vol. 83, no. 20, 17 November 1975, Columbus, Ohio, US; abstract no. 166398z, page 136;
CHEMICAL ABSTRACTS, vol. 121, no. 2, 11 July 1994, Columbus, Ohio, US; abstract no. 14337u, page 324;
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Claims:
1. C L I M S The way of talc treatment, distinguished with mixing 74 up to 89 weight % of water, 10 up to 20 weight % of talc and 1 up to 6 weight % of hydro¬ chloric acid, and the resulting substance is heated at constant stirring during 0.5 up to 6 hours to the temperature 40°C up to 60°C and it is maintained at this temperature during 1 hour up to 6 hours, subsequently there is separated sediment from the reaction mixture and following the adjustment of its acidity to the pH value 5 up to 8 it is mixed with water and sulphuric acid in the ratio of 10 up to volume % of sediment,74 up to 89 volume % of water and 1 up to 6 volume % of sulphuric acid,connected with the laborato¬ ry temperature, and at constant stirring the re¬ action mixture is heated during 0.5 up to 6 hours to the temperature 75°C up to 125°C and it is maintained at this temperature until the time when there is reached a quasi unchangeable value of the iron content in the reaction mixture and then the sediment is separated, its acidity is adjusted to the pH value 6 up to 8 and subse¬ quently it is dried and sterilized at the tempe¬ rature 160°C up to 250°C during two up to four hours .
2. The way in accordance with the point 1, distin¬ guished with the fact, that before drying and sterilization there is performed the operation of bleaching.
3. The way in accordance with the points 1 and 2, distinguished with the fact, that after the ope¬ ration of drying and sterilization the particles in the agglomerates are separated from each other.
Description:
METHOD OF TREATMENT OF TALC

Background of the invention

Talc belongs among very important technical raw materials and it is utilizable in various indu¬ stries, as for instance for production of electro- technical ceramics products, heat-resistant vessels, stoves, in cosmetics, etc. It is a very important entering raw material at the production of medica¬ ments where it fulfills the function of a sliding substance .

Each application of talc requires certain degree of processing of the mineral, whereby for the use of talc for the purposes of medicaments production there is inevitable such treatment of the mineral which creates conditions for an achievement of a peak-quality product complying with the regulations connected with quality parameters of entering subs¬ tances for medicaments production.As the consequen¬ ce of the above mentioned fact the technological process of talc treatment is very demanding from the view of costs.There is not coped-with in a suf¬ ficient degree the talc processing technology for the application at the medicaments production out of a starting product, quality parameters of which are at a lower level. In question is for instance the talc with the parameters, where e.g. in the weight unit there is the content of ferric oxide 5 % and more, the content of substances soluble in an acidic environment 40.4 % and more, and substan¬ ces soluble in water 0.08 % and more, alkaline and acidic substances are blue and carbonates are being developed. The loss by annealing is usually 18 % and more.

Brief description of the invention

The invention concerns talc,as an entering raw material for production of medicaments, at which it tackles the the procedure of its treatment with the aim to obtain an outlet product of a less valuable raw material.

Summary of the invention

The above mentioned shortcomings are in a si¬ gnificant degree removed by the way of talc proces¬ sing in accordance with the invention,the substance of which consists in the mixing-up 74 up to 89 weight % of water, 10 up to 20 weight * of talc and 1 up to 6 weight % of hydrochloric acid and the re¬ sulting mixture is heated at constant stirring in 0.5 up to 6 hours to the temperature 40°C up to 60°C and it is maintained at this temperature during 1 up to 6 hours. In the reaction mixture there is afterwards separated the sediment and following the adjustment of its acidity to the value pH 5 up to 8 it is mixed with water and sulphuric acid in the ratio 10 up to 20 volume * of sediment, 74 up to 89 volume % of water and 1 up to 6 volume % of sulphu¬ ric acid in accordance with the laboratory tempera¬ ture, and at constant stirring is the reaction mix¬ ture heated during 0.5 hour up to 6 hours to the temperature 75°C up to 125°C and it is kept at this temperature until the time when there is reached a quasi unchangeable value of iron content in the reaction mixture,and then the sediment is separated, its acidity is adjusted to the pH value 5 up to 8 and subsequently it is dried and sterilized at the temperature 160°C up to 250°C during two up to four hours.

The technological procedure,which is an object

of protection, is outstanding especially because of its contribution consisting in the ability to treat talc in an economically advantageous way for the purposes of medicaments production, starting para¬ meters of which reach besides the standard level also a lower and even very bad level. The resulting product produced by the proposed procedure reaches the same and in some properties even better parame¬ ters than are ones reached by the technologies of talc treatment at which the entering product has higher quality parameters. Talc treated in the way in accordance with the invention reaches the value of loss by annealing less than 5% , content of sub¬ stances soluble in water at the temperature 105°C is less than 0.155K,content of substances soluble in acidic environment is less than 1.6*, content of iron in percentual expression is less than 0 .4% and in weight expression it is less than 69 mg/kg, whiteness is at least 67.0%. The substance does not develop carbonates and its alkaline components are of blue colour and acidic components are of green colour.

Example of invention realization

To the purpose of proving the feasibility of the invention in the way of obtaining data on quality parameters of the resulting product of the process there were performed several tests. he pro¬ cedure of individual operations and the conditions at which they were realized are described in details in following examples:

Example No. 1

There was formed the water solution consisting of 0.6 kg of talc and of four liters of water. To

the solution there was gradually added 0.1 liter of hydrochloric acid, 37%, with the density 1.18, fter¬ wards the substance was heated and maintained at the temperature 52°C up to 54°C during the time 120 minutes at constant stirring, and following its se¬ dimentation and separation of supernatant it was washed with water 4 times with the quantity of wa¬ ter 10 liters, until there was reached the acidity of sediment with the pH value 6.5. Subsequently the sediment was diluted with water in the quantity 4 liters and into the solution there was gradually added 0.2 liter of 96% sulphuric acid with the den¬ sity 1.83, then the reaction mixture was heated and at constant stirring kept at the temperature 90°C up to 95°C during 285 minutes,when there was reached the quasi stable value of the iron content. Follow¬ ing the finishing of this operation the solid com¬ ponents were separated,the sediment was washed with water four times with the quantity of water 10 li¬ ters, by which there was reached the acidity value of the sediment of pH 7. fterwards the sediment was dried and sterilized at the temperature 160°C du¬ ring 240 minutes. The result of the mentioned pro¬ cedure was the talc which had following parameters: loss by annealing 4.82%, content of substances so¬ luble in warm water at 105°C 0.11%, content of sub¬ stances soluble in the acidic environment 1.56%, content of iron in the percentual expression 0.023%, carbonates were not being developed, alkaline sub¬ stances were of blue colour and acidic substances were of green colour.There was reached the whiteness of the product of 67.8%.

Example No. 2

To the water solution containing 0.8 of talc

and four liters of water there was gradually added 0.05 liter of 37% hydrochloric acid with the densi¬ ty 1.18 and the substance was heated to the tempe¬ rature 56°C and at this temperature it was maintained at constant stirring during 1 hour and 35 minutes. Further there were separated by the se¬ dimentation the solid components and they were washed manually four times with the quantity of wa¬ ter 10 liters,when was reached the acidity value of sediment of pH 6.5. Then the sediment was diluted with ten liters of water and into the resulting wa¬ ter solution there was gradually added 0.4 1 of 96% sulphuric acid with the density 1.83, the reaction solution was at constant stirring heated and maintained at the temperature 100°C for two hours, when there was reached a quasi stable value of iron content in the solution. Afterwards the solid com¬ ponents were separated by sedimentation and the se¬ diment was washed four times always with the quan¬ tity of water 10 liters, by which there was reached the acidity value of the sediment of pH 7. Then the sediment was dried and sterilized at the temperatu¬ re 160°C.

The result of the mentioned process was the product characterized with following parameters: loss by annealing 3.99%, content of substances so¬ luble in warm water at 105°C 0.11%, content of sub¬ stances soluble in the acidic environment 0.66%, content of iron in the percentual expression 0.011%, carbonates were not being developed, alka¬ line substances were of blue colour and acidic substances were of green colour. There was reached the whiteness of the product of 68.1%.

It is necessary to add to the method of talc treatment,that it is advantageous to use the hydro-

chloric acid and sulphuric acid in higher concentra¬ tions. Agglomerates of resulting product were dis¬ integrated by screening, sieving. n increase of the whiteness level of the product can be achieved by common bleaching methods. Mixing of the components can be realized in such a way, that all components are added at the same time, or at first there are mixed two components and then there is being added further one.

The invention is utilizable in the chemical industry and the result of the procedure, which is subject to the protection, forms an important ente¬ ring raw material for pharmaceutical industry at the production of tabletted medicaments and oint¬ ment bases.