Title:
METHOD FOR DETECING/ENRICHING TRICHOGENIC DERMAL CELLS, CELLS AND USE THEREOF IN METHOD OF TREATMENT OF HAIR LOSS
Document Type and Number:
WIPO Patent Application WO/2011/011677
Kind Code:
A3
Abstract:
Methods for identifying trichogenic dermal cells, including dermal papilla cells and dermal sheath cells, capable of inducing hair follicle formation when injected into skin are provided. Biomarkers have been discovered that can be used to detect, identify, and distinguish trichogenic dermal cells, i.e., that are able to induce hair follicle formation, from non- trichogenic skin cells. Populations of enriched trichogenic dermal cells can be produced by selecting for and enriching for dermal cells that the disclosed biomarkers. These enriched trichogenic dermal can be used for inducing hair follicle formation.
Inventors:
TEUMER JEFFREY KEELER (US)
MASTYUGIN VLADIMIR (US)
QIAO JIZENG (US)
ZAWADZKA AGATHA (US)
MASTYUGIN VLADIMIR (US)
QIAO JIZENG (US)
ZAWADZKA AGATHA (US)
Application Number:
PCT/US2010/043042
Publication Date:
March 24, 2011
Filing Date:
July 23, 2010
Export Citation:
Assignee:
ADERANS RES INST INC (US)
TEUMER JEFFREY KEELER (US)
MASTYUGIN VLADIMIR (US)
QIAO JIZENG (US)
ZAWADZKA AGATHA (US)
TEUMER JEFFREY KEELER (US)
MASTYUGIN VLADIMIR (US)
QIAO JIZENG (US)
ZAWADZKA AGATHA (US)
International Classes:
C12N5/071
Domestic Patent References:
| WO2009086000A2 | 2009-07-09 |
Foreign References:
| EP1757307A1 | 2007-02-28 |
Other References:
WU JIN-JIN ET AL: "Hair follicle reformation induced by dermal papilla cells from human scalp skin.", ARCHIVES OF DERMATOLOGICAL RESEARCH SEP 2006 LNKD- PUBMED:16897077, vol. 298, no. 4, September 2006 (2006-09-01), pages 183 - 190, XP002600300, ISSN: 0340-3696
HIRAM DE ALMEIDA ET AL: "Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts", ARCHIVES OF DERMATOLOGICAL RESEARCH ; FOUNDED IN 1869 AS ARCHIV FÜR DERMATOLOGIE UND SYPHILIS, SPRINGER, BERLIN, DE LNKD- DOI:10.1007/S00403-005-0587-3, vol. 297, no. 3, 1 September 2005 (2005-09-01), pages 121 - 126, XP019341158, ISSN: 1432-069X
HIRAM DE ALMEIDA ET AL: "Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts", ARCHIVES OF DERMATOLOGICAL RESEARCH ; FOUNDED IN 1869 AS ARCHIV FÜR DERMATOLOGIE UND SYPHILIS, SPRINGER, BERLIN, DE LNKD- DOI:10.1007/S00403-005-0587-3, vol. 297, no. 3, 1 September 2005 (2005-09-01), pages 121 - 126, XP019341158, ISSN: 1432-069X
Attorney, Agent or Firm:
PABST, Patrea L. et al. (1545 Peachtree Street N.E.,Suite 32, Atlanta GA, US)
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