METHOD FOR UBIQUITINATION OF RUNX

WIPO Patent Application WO/2006/132248

A1

[PROBLEMS] To find a protein capable of interacting with RUNX to regulate the action of RUNX, provide a means for regulating the action of RUNX and provide a means useful for the prevention and/or treatment of a disease caused by RUNX abnormality. [MEANS FOR SOLVING PROBLEMS] It is found that NEDD4 which is a HECT E3 ligase can ubiquitinate RUNX to cause the degradation of RUNX. Based on this finding, there are provided a method for the ubiquitination of RUNX or a method for the degradation of RUNX which is characterized by using NEDD4; a ubiquitinating agent or a degrading agent for RUNX; a method for the inhibition of the ubiquitination or the degradation of RUNX by NEDD4; a ubiquitination inhibitor or a degradation inhibitor for RUNX; a method for the identification of a compound capable of inhibiting or enhancing the ubiquitination of RUNX; a method for the identification of a compound capable of inhibiting or enhancing the binding between RUNX and NEDD4; a reagent kit; and a method for the prevention and/or treatment of a disease caused by RUNX abnormality.

KUDO GEN (JP)
TAKATA TAKEHIKO (JP)
HAYASAKA HARUNA (JP)
DOI HIROFUMI (JP)
KIKUCHI YASUHIRO (JP)

PCT/JP2006/311333

December 14, 2006

June 06, 2006

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DAIICHI SEIYAKU CO (JP)
KUDO GEN (JP)
TAKATA TAKEHIKO (JP)
HAYASAKA HARUNA (JP)
DOI HIROFUMI (JP)
KIKUCHI YASUHIRO (JP)

C12N15/09; A61K45/00; A61K45/06; A61P35/00; A61P43/00; C12N9/99; C12P21/02; C12Q1/02; C12Q1/25; C12Q1/28; G01N33/15; G01N33/50

WO2002090549A2	2002-11-14
WO2000022110A2	2000-04-20

JP2004529619A	2004-09-30
JP2005204557A	2005-08-04

Shoji, Takashi (2-10 Iwamotocho 3-chom, Chiyoda-ku Tokyo 32, JP)

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