METHOD FOR ULTRASOUND TRIGGERED DRUG DELIVERY USING HOLLOW MICROBUBBLES WITH CONTROLLED FRAGILITY

Title:

METHOD FOR ULTRASOUND TRIGGERED DRUG DELIVERY USING HOLLOW MICROBUBBLES WITH CONTROLLED FRAGILITY

Document Type and Number:

WIPO Patent Application WO2003034975

Kind Code:

A3

Abstract:

A method is provided for site specific delivering therapeutic or diagnostic agents to a region in a fluid-filled cavity, vessel or tissue using an agent-loaded microbubble population. The population has controlled fragility characterized by a uniform wall thickness to diameter ratio which defines the discrete threshold intensity value of ultrasonic power where microbubble rupture occurs in the population. The location of the microbubble population may be monitored by ultrasound to determine its presence at the region prior to application of the ultrasonic power to rupture to microbubbles.

Inventors:

CONSTON STANLEY R (US)
YAMAMOTO RONALD K (US)
OTTOBONI THOMAS B (US)
TICKNER GLENN E (US)

Application Number:

PCT/US2002/033858

Publication Date:

November 06, 2003

Filing Date:

October 22, 2002

Export Citation:

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Assignee:

POINT BIOMEDICAL CORP (US)
CONSTON STANLEY R (US)
YAMAMOTO RONALD K (US)
OTTOBONI THOMAS B (US)
TICKNER GLENN E (US)

International Classes:

A61B8/00; A61B8/14; A61H1/00; A61K9/00; A61K9/50; A61K41/00; A61K47/48; A61K49/22; A61M37/00; (IPC1-7): A61B8/14

Foreign References:

US5580575A	1996-12-03
US5650156A	1997-07-22
US6171246B1	2001-01-09
US5190766A	1993-03-02
US6340348B1	2002-01-22
US6319204B1	2001-11-20
US5585112A	1996-12-17

Other References: