Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR UPREGULATION OF THIOREDOXIN EXPRESSION IN STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2019/168364
Kind Code:
A1
Abstract:
The present invention relates to a method for upregulation of thioredoxin expression in stem cells and, more particularly, to a method for upregulation of thioredoxin expression in stem cells, the method comprising a step of culturing stem cells in a hypoxic condition, the stem cells having an upregulated expression of thioredoxin by the same method, and a use of the stem cells in treatment of ischemic brain disease. When cultured in a hypoxic condition, stem cells are allowed to increase the expression of thioredoxin and stem cells that have an upregulated expression level of thioredoxin exhibiting an excellent therapeutic effect on ischemic brain disease can be obtained by the method. Thus, the stem cells can be usefully applied in the prevention or treatment of ischemic brain disease.

More Like This:
JPH10226700IMMUNOASSAY FOR DETECTING MIA
WO/1998/048276NON-OBLIGATE PREDATOR BACTERIUM $i(BURKHOLDERIA CASIDAE) AND USES THEREOF
Inventors:
PARK WON SOON (KR)
CHANG YUN SIL (KR)
SUNG DONG KYUNG (KR)
Application Number:
PCT/KR2019/002408
Publication Date:
September 06, 2019
Filing Date:
February 28, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
C12N5/00; A61K35/12; A61K35/28; A61P9/10; C12N5/0775
Domestic Patent References:
WO2017075136A12017-05-04
WO1998032863A21998-07-30
Foreign References:
US20160331875A12016-11-17
Other References:
PARK, K.-J. ET AL.: "Expression Pattern of the Thioredoxin System in Human Endothelial Progenitor Cells and Endothelial Cells Under Hypoxic Injury", KOREAN CIRCULATION JOURNAL, vol. 40, no. 12, 2010, pages 651 - 658, XP055635344
TAKAGI, Y. ET AL.: "Overexpression of thioredoxin in i transgenic mice attenuates focal ischemic brain damage", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (PNAS), vol. 96, no. 7, 1999, pages 4131 - 4136, XP055635346
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: METHOD FOR PROVIDING VIRTUAL REALITY CINEMA SERVICE AND APPARATUS THEREFOR

Next Patent: POLYMER, COATING COMPOSITION COMPRISING SAME, AND ORGANIC LIGHT EMITTING ELEMENT USING SAME