Title:
METHOD OF USING GENETIC MARKERS, SNPS AND/OR INDELS TO DETERMINE RESPONSIVENESS TO IL-10 TREATMENT
Document Type and Number:
WIPO Patent Application WO/2021/142349
Kind Code:
A1
Abstract:
The application relates to the discovery of novel gene expression profiles and/or single nucleotide polymorphisms (SNP) and/or insertions or deletions of bases (INDEL) profiles that correlate with a subject's positive receptiveness to Interleukin 10 (IL-10) or IL-10 based agent treatments. The application also relates to methods of treating patients with an IL-10 or IL-10 based agent treatment by screening, examining, or determine patients possessing a gene expression profile and/or SNP and/or INDEL profile most receptive to the treatment.
More Like This:
Inventors:
MUMM JOHN (US)
Application Number:
PCT/US2021/012814
Publication Date:
July 15, 2021
Filing Date:
January 08, 2021
Export Citation:
Assignee:
DEKA BIOSCIENCES INC (US)
International Classes:
C12Q1/6886
Foreign References:
| US20110256091A1 | 2011-10-20 |
Other References:
KOSS K, SATSANGI J, FANNING G C, WELSH K I, JEWELL D P: "Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies", GENES AND IMMUNITY, vol. 1, no. 3, 8 February 2000 (2000-02-08), pages 189 - 190, XP055841170, DOI: 10.1038/sj.gene.6363657
REICH ET AL.: "Promoter Polymorphisms of the Genes Encoding Tumor Necrosis Factor-a and Interleukin-1b are Associated with Different Subtypes of Psoriasis Characterized by Early and Late Disease Onset", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 118, no. 1, 1 January 2002 (2002-01-01), pages 155 - 163, XP002231844, DOI: 10.1046/j.0022-202x.2001.01642.x
FRANKE ET AL.: "Sequence variants in IL 10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility", NATURE GENETICS, vol. 40, no. 11, November 2008 (2008-11-01), pages 1319 - 1323, XP002521905, DOI: 10.1038/NG.221
MUMM ET AL.: "IL -10 Elicits IFNg-Dependent Tumor Immune Surveillance", CANCER CELL, vol. 20, no. 6, 2 November 2011 (2011-11-02), pages 781 - 796, XP028339558, DOI: 10.1016/j.ccr.2011.11.003
See also references of EP 4087947A4
REICH ET AL.: "Promoter Polymorphisms of the Genes Encoding Tumor Necrosis Factor-a and Interleukin-1b are Associated with Different Subtypes of Psoriasis Characterized by Early and Late Disease Onset", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 118, no. 1, 1 January 2002 (2002-01-01), pages 155 - 163, XP002231844, DOI: 10.1046/j.0022-202x.2001.01642.x
FRANKE ET AL.: "Sequence variants in IL 10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility", NATURE GENETICS, vol. 40, no. 11, November 2008 (2008-11-01), pages 1319 - 1323, XP002521905, DOI: 10.1038/NG.221
MUMM ET AL.: "IL -10 Elicits IFNg-Dependent Tumor Immune Surveillance", CANCER CELL, vol. 20, no. 6, 2 November 2011 (2011-11-02), pages 781 - 796, XP028339558, DOI: 10.1016/j.ccr.2011.11.003
See also references of EP 4087947A4
Attorney, Agent or Firm:
YAEN, Christopher H. et al. (US)
Download PDF:
Previous Patent: WIRELESS CHARGING TRANSFER APPARATUS AND METHODS
Next Patent: FLEXIBLE DIRECTIONAL VEHICLE WARNING LIGHT
Next Patent: FLEXIBLE DIRECTIONAL VEHICLE WARNING LIGHT