Title:
ANALYSIS/DIAGNOSIS METHOD UTILIZING RNA MODIFICATION
Document Type and Number:
WIPO Patent Application WO/2019/163900
Kind Code:
A1
Abstract:
The present application provides a novel method for analyzing a biological condition or a medical condition. It is now found that information about the modification of RNA can be used for the analysis of a biological condition or a medical condition. On the basis of this finding, the present invention provides a novel method for analyzing a biological condition or a medical condition. According to the present invention, it becomes possible to analyze various biological conditions or medical conditions including diseases, and it also becomes possible to satisfactorily predict cancer (e.g., pancreatic cancer, colorectal cancer, stomach cancer) in an early stage.
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Inventors:
ISHII HIDESHI (JP)
KONNO MASAMITSU (JP)
MORI MASAKI (JP)
KONNO MASAMITSU (JP)
MORI MASAKI (JP)
Application Number:
PCT/JP2019/006588
Publication Date:
August 29, 2019
Filing Date:
February 21, 2019
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C12Q1/6869; C12M1/00; C12Q1/6806; C12Q1/6872; C12Q1/6888; G01N33/50; C12N15/09; C12N15/10
Domestic Patent References:
| WO2014136870A1 | 2014-09-12 | |||
| WO2018124235A1 | 2018-07-05 |
Foreign References:
| JP2016123338A | 2016-07-11 | |||
| JP2017517262A | 2017-06-29 | |||
| JP2008502336A | 2008-01-31 | |||
| JP2018029494A | 2018-03-01 |
Other References:
MA JIN-ZHAO ET AL.: "METTL14 Suppresses the Metastatic Potential of Hepatocellular Carcinoma by Modulating N6-Methyladenosine-Dependent Primary MicroRNA Processing", HEPATOLOGY, vol. 65, no. 2, February 2017 (2017-02-01), pages 529 - 543, XP055633363
DAI D ET AL.: "N6-methyladenosine links RNA metabolism to cancer progression", CELL DEATH AND DISEASE, vol. 9, no. 124, 26 January 2018 (2018-01-26), pages 1 - 13, XP055488069
ISHII: "Development of high definition technology to measure methylation modification within microRNA molecule in single cell", ANNUAL REPORT OF NAKATANI FOUNDATION FOR ADVANCEMENT OF MEASURING TECHNOLOGIES IN BIOMEDICAL ENGINEERING, vol. 31, 20 March 2018 (2018-03-20), pages 100 - 107, XP009522993
PAGLIARINI DJ, CELL METAB., vol. 24, no. 1, 12 July 2016 (2016-07-12), pages 13 - 4
NAT GENET., vol. 32, December 2002 (2002-12-01), pages 526 - 32
CLARK J ET AL., NAT METHODS, vol. 8, no. 3, March 2011 (2011-03-01), pages 267 - 272
JURGEN H: "Mass Spectrometry", 2014, MARUZEN PUBLISHING
J. ENGBERG ET AL., EUR. J. BIOCHEM, vol. 41, 1974, pages 321 - 328
CUI ET AL., BIOINFORMATICS, vol. 32, no. 12, 2016, pages i378 - i385
SIJIA HUANG ET AL., FRONT GENET., vol. 8, 2017, pages 84
YEHUDIT HASIN ET AL., GENOME BIOL., vol. 18, 2017, pages 83
SANCHEZ ET AL., NATURE, vol. 468, no. 7320, 4 November 2010 (2010-11-04), pages 112 - 6
JEAN-MICHEL ET AL., CELL, vol. 155, no. 4, 7 November 2013 (2013-11-07), pages 793 - 806
CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, Retrieved from the Internet
KATSUTOSHI SATO ET AL., CANCER SCI., vol. 108, no. 10, October 2017 (2017-10-01), pages 2004 - 2010
KATSUTOSHI SATO ET AL., SCI REP., vol. 8, 2018, pages 1458
KOSUKE TAKETO ET AL., INT J ONCOL., vol. 52, no. 2, February 2018 (2018-02-01), pages 621 - 629
SHABALIN AA., BIOINFORMATICS, 12 February 2018 (2018-02-12)
JEONG H, FRONT NEUROSCI., vol. 12, 2 February 2018 (2018-02-02), pages 31
GUPTA R ET AL., PROTEOMICS, 19 February 2018 (2018-02-19)
See also references of EP 3763826A4
DAI D ET AL.: "N6-methyladenosine links RNA metabolism to cancer progression", CELL DEATH AND DISEASE, vol. 9, no. 124, 26 January 2018 (2018-01-26), pages 1 - 13, XP055488069
ISHII: "Development of high definition technology to measure methylation modification within microRNA molecule in single cell", ANNUAL REPORT OF NAKATANI FOUNDATION FOR ADVANCEMENT OF MEASURING TECHNOLOGIES IN BIOMEDICAL ENGINEERING, vol. 31, 20 March 2018 (2018-03-20), pages 100 - 107, XP009522993
PAGLIARINI DJ, CELL METAB., vol. 24, no. 1, 12 July 2016 (2016-07-12), pages 13 - 4
NAT GENET., vol. 32, December 2002 (2002-12-01), pages 526 - 32
CLARK J ET AL., NAT METHODS, vol. 8, no. 3, March 2011 (2011-03-01), pages 267 - 272
JURGEN H: "Mass Spectrometry", 2014, MARUZEN PUBLISHING
J. ENGBERG ET AL., EUR. J. BIOCHEM, vol. 41, 1974, pages 321 - 328
CUI ET AL., BIOINFORMATICS, vol. 32, no. 12, 2016, pages i378 - i385
SIJIA HUANG ET AL., FRONT GENET., vol. 8, 2017, pages 84
YEHUDIT HASIN ET AL., GENOME BIOL., vol. 18, 2017, pages 83
SANCHEZ ET AL., NATURE, vol. 468, no. 7320, 4 November 2010 (2010-11-04), pages 112 - 6
JEAN-MICHEL ET AL., CELL, vol. 155, no. 4, 7 November 2013 (2013-11-07), pages 793 - 806
CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, Retrieved from the Internet
KATSUTOSHI SATO ET AL., CANCER SCI., vol. 108, no. 10, October 2017 (2017-10-01), pages 2004 - 2010
KATSUTOSHI SATO ET AL., SCI REP., vol. 8, 2018, pages 1458
KOSUKE TAKETO ET AL., INT J ONCOL., vol. 52, no. 2, February 2018 (2018-02-01), pages 621 - 629
SHABALIN AA., BIOINFORMATICS, 12 February 2018 (2018-02-12)
JEONG H, FRONT NEUROSCI., vol. 12, 2 February 2018 (2018-02-02), pages 31
GUPTA R ET AL., PROTEOMICS, 19 February 2018 (2018-02-19)
See also references of EP 3763826A4
Attorney, Agent or Firm:
YAMAMOTO Shusaku et al. (JP)
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